Hemomine is an herbal blend comprising Angelicae Gigantis Radix and other herbs known to have immunomodulatory effects. We examined the immunopotentiating effect of this on cyclophosphamide (CPA)-induced immunosuppression. Male mice were assigned one six groups: intact control five CPA treatment groups (one control, reference (β-glucan), three with application hemomine at different concentratio...

We evaluated the effect of dietary curcumin supplementation on antioxidant capacity liver and resistance spleen to ammonia stress in great amberjack ( Seriola dumerili ). Three isonitrogenous isolipidic test diets were prepared by supplementing incremental levels at 0 mg/kg (CUR0%, control), 100 (CUR0.01%), 200 (CUR0.02%), respectively. Each diet was randomly assigned triplicate groups 15 fish ...

The protein tyrosine phosphatase PTPN22 inhibits T cell activation by dephosphorylating some essential proteins in the receptor (TCR)-mediated signaling pathway, such as lymphocyte-specific kinase (Lck), Src family kinases Fyn, and phosphorylation levels of Zeta-chain-associated kinase-70 (ZAP70). For first time, we have successfully produced CS transgenic mice which activity is suppressed. Not...

postmortem examination of a 5.5-year-old holstein cow with history of sudden death showed a veryhuge spleen (120 × 45 × 10 cm) associated with severe haemoperitoneum. histopathological findingsincluded extensive infiltration of medium to large sized lymphocytic and lymphoblastic cells with smallamounts of cytoplasm, round nuclei with coarsely granular chromatin in the spleen, and limited foci o...

The effects of nonspecific phytomitogens on primary plaque-forming cell (PFC) responses of mouse spleen cells to heterologous erythrocytes in vitro were studied. Spleen cell cultures treated with concanavalin A or phytohemagglutinin in vitro or established with spleen cells derived from mice injected with concanavalin A 24 h previously were similarly affected. In both cases, submitogenic doses ...

In mice, infection with Leishmania tropica initially produced a nonspecific enhancement of the immune response to sheep erythrocytes as measured both in vitro and in vivo. Subsequently, the spleen cell responses of susceptible mice (BALB/c) to sheep erythrocytes and T- and B-cell mitogens in vitro decreased dramatically, whereas those of the resistant strain (C57BL/6) returned to normal. Analys...

1. Tolerance of male skin isografts has been regularly produced in female mice of the C57B1 strain sublines 1, 4, and 6 during adult life by repeated injection of completely disrupted spleen cells derived from male donors. The tolerant state is long-lasting since such grafts have remained in place more than 9 months. 2. Prolonged survival of homotransplants of skin has regularly been produced i...

Propoxure (PPX) is a well-known carbamate insecticide, which has been used for several decades in the world and Iran in agriculture and public health programs. However, there is no clear investigation toward its immunotoxicity as yet. In this study, we examined the effects of subchronic i.p. exposure of PPX on humoral (PFC & HA) and cellular (DTH) responses, and also monitored T-Cell subtypes u...

The presence of hypersplenism and or respond to intravenous particulate functional asplenia occurring concomiantigen, retains the splenic reservoir tantly in a child with sickle cell anemia function to pool platelets. This reserprompted a study of the splenic platevoir function is lost in the older patient let reservoir in this hemoglobinopathy. in whom the spleen has become autoThe young child...