Tumor cells must overcome apoptosis to survive throughout metastatic dissemination and distal organ colonization. Here, we show in the Polyoma Middle T mammary tumor model that N-cadherin (Cdh2) expression causes Slug (Snai2) upregulation, which in turn promotes carcinoma cell survival. Slug was dramatically upregulated in metastases relative to primary tumors. Consistent with a role in metasta...

Tumor cells must overcome apoptosis to survive throughout metastatic dissemination and distal organ colonization. Here, we show in the Polyoma Middle T mammary tumor model that N-cadherin (Cdh2) expression causes Slug (Snai2) upregulation, which in turn promotes carcinoma cell survival. Slug was dramatically upregulated in metastases relative to primary tumors. Consistent with a role in metasta...

BACKGROUND AND AIMS Slug is an E-cadherin repressor and a suppressor of PUMA (p53 upregulated modulator of apoptosis) and it has recently been demonstrated that Slug plays an important role in controlling apoptosis. In this study, we examined whether Slug's ability to silence expression suppresses the growth of leukemia HL-60 cells and/or sensitizes leukemia HL-60 cells to adriamycin (ADR) thro...

The study of two-phase fluid flow behavior in hydraulic structures such as pressurized flow tunnels, culverts, sewer pipes, junctions and other similar conduits is of great importance. A two-phase mixture flowing in a pipe can exhibit several interfacial geometries such as bubbles, slugs or films, depending on the fluid and hydrodynamic properties of flow. The main variables, giving rise to a v...

stimulated wells completed in commingled reservoirs, i.e., This paper examines tic transient pressure response from slug reservoirs in which the layers communicate only at the wellbore tests in wells completed in multiple, hy&aulically fractured coal and not in the fractures or reservoir. Under these conditions, our seams. We developed a model for stimulated wells producing model is applicablee...

PURPOSE We assessed the relevance of Slug (SNAI2) for apoptosis resistance and invasion potential of neuroblastoma cells in vitro and in vivo. EXPERIMENTAL DESIGN We evaluated the effect of imatinib mesylate on invasion and analyzed the genes modulated by imatinib mesylate treatment in neuroblastoma cells. Slug expression, inhibited by imatinib mesylate treatment, was knocked down in neurobla...

We investigated the expression of slug in a large set of lung squamous and adenocarcinomas to determine common or dissimilar features in its expression in these two most common forms of lung cancer. To investigate slug related tumor spread we studied the expression of vimentin, claudin 1, MMP2 and MMP9 in these tumors and their relation to slug. Addition, cell invasion assays, mRNA analysis and...

Colorectal cancer is one of the most common alimentary malignancies. Slug has been shown to be an ideal target for cancer gene therapy by numerous studies due to its strong anti-apoptotic effect. The elevated expression of Slug is a frequent genetic abnormality observed in colorectal cancer. In the present study, a Slug short hairpin RNA (shRNA) expression vector that was able to efficiently in...

Gas assisted atomization is becoming increasingly important in many industrial applications such as physical, chemical and petroleum processes. In order to achieve proper atomization it is crucial to have proper mixing of gas (air) and liquid (water) in the feeding conduit before it enters into the nozzle. The flow regime, as well as the flow pattern and structure of the flow, are some of the i...

Recent studies have shown that high miR-155 expression was associated with poor prognosis in patients with acute myelogeneous leukemia (AML). Furthermore, targeting miR-155 results in monocytic differentiation and apoptosis. However, the exact role and mechanisms of miR-155 in human AML remains speculative. HL-60 cells were treated with anti-miR-155 for 72 h. Cell growth and apoptosis in vitro ...