Objective: This study aimed to design a formula using Design-Expert software obtain optimal Self-Nanoemulsifying Drug Delivery System (SNEDDS) formulas and analyze nanospray characteristics of SNEDDS.
 Methods: The began with preparing ethanol extract from Melastoma malabathricum. was then fractionated ethyl acetate. formulation stage solubility test malabathricum fraction gentamicin (MFG)...

Antihypertensive drugs undergo first-pass metabolism and therefore have low oral bioavailability. It causes an increase in the frequency of drug use concentration fluctuations that affect patient comfort. The sustained release tablet formulation was chosen because it can deliver active substance with good An antihypertensive be used is celery extract contains flavonoids, so a made using xanthan...

We present Barrier-based Simplex (Bb-Simplex), a new, provably correct design for runtime assurance of continuous dynamical systems. Bb-Simplex is centered around the Control Architecture, which consists high-performance advanced controller not guaranteed to maintain safety plant, verified-safe baseline controller, and decision module that switches control plant between two controllers ensure w...

We study the problem of adsorption and collapse transition of a linear polymer chain situated in a fractal container represented by a 4-simplex lattice and interacting with a surface adsorbed linear polymer chain. The adsorbed chain monomers act as pinning sites for the polymer chain. This problem has been solved exactly using real space renormalization group transformation. The resulting phase...

During the last decades a number of studies on modifications and improvement of the original algorithm have been published. The first design matrix is however one aspect of simplex optimization that has raised substantially less interest, despite the observation of its importance for the speed of convergence by Nelder and Mead. This is probably due to the fact that Spendley et al already in the...

We show that Ln is isomorphic to the cone over the lattice pyramid of a reflexive simplex whose Ehrhart h∗-polynomial is given by the (n − 1)st Eulerian polynomial, and prove that lecture hall cones admit regular, flag, unimodular triangulations. After explicitly describing the Hilbert basis for Ln, we conclude with observations and a conjecture regarding the structure of unimodular triangulati...

In this paper, we present FPT-algorithms for special cases of the shortest lattice vector, integer linear programming, and simplex width computation problems, when matrices included in the problems' formulations are near square. The parameter is the maximum absolute value of rank minors of the corresponding matrices. Additionally, we present FPT-algorithms with respect to the same parameter for...

This paper presents a new inhomogeneous solid modeling paradigm for engineering design. The proposed paradigm can represent, model, and render multi-dimensional, physical attributes across any volumetric objects of complicated geometry and topology. A modeled object is formulated with a trivariate simplex spline defined over a tetrahedral decomposition of its 3D domain. Heterogeneous material a...

Poly-herbals combination was applied to enhance biological activity, particularly antioxidant activity. This present study purposed assess the synergistic interaction of a five traditional Indonesian herbal plants through simultaneous and integrated statistical technique. The were extracted using maceration, purification conducted before extraction eliminate ballast compounds. A simplex ...

Background : sunlight contains ultraviolet that happened skin problem from mild to severe. To overcome these problems, a sunscreen made natural materials is relatively safe. CKersen Leaves (Muntingia calabura L.) contain total flavonoids and phenolics can be used as active ingredients. In lotion preparations, emulsifiers affect the physical properties of lotions. Objective this research study o...