Highlights d Multiple mLEDs and recording sites were fabricated monolithically on silicon d Spikes were robustly induced using ultra-low optical power (60 nW) d Neurons 50 mm apart were controlled independently in CA1 of freely moving mice d Deep and superficial parts of CA pyramidal layer form distinct ripple generators In Brief Recording and stimulating multiple individual neurons is critical...

As transistor dimensions are scaled down in accordance with Moore's Law to provide for improved performance and cost per function, variability in transistor performance grows in significance and can present a major challenge for achieving high yield in the manufacture of integrated circuits utilizing transistors with sub-30 nm gate lengths. Increased variability in the threshold voltage (V T) o...

The tunnel field-effect transistor (TFET) is a potential candidate for replacing the reverse diode and providing secondary path in whole-chip electrostatic discharge (ESD) protection network. In this paper, ESD characteristics of traditional point TFET, line TFET Ge-source are investigated using technology computer-aided design (TCAD) simulations, an improved TFET-based scheme proposed. It foun...

Pompe disease is an inherited lysosomal storage disorder that results from a deficiency in acid α-glucosidase (GAA) activity due to mutations in the GAA gene. Pompe disease is characterized by accumulation of lysosomal glycogen primarily in heart and skeletal muscles, which leads to progressive muscle weakness. We have shown previously that the small molecule pharmacological chaperone AT2220 (1...

Pompe disease is a form of muscular dystrophy due to lysosomal storage of glycogen caused by deficiency of acid α-glucosidase (GAA). Respiratory failure in Pompe disease has been attributed to respiratory muscle dysfunction. However, evaluation of spinal tissue from Pompe patients and animal models indicates glycogen accumulation and lower motoneuron pathology. We hypothesized that restoring GA...

The present study aims to determine the best technique of Guanidinoacetic acid (GAA) supplementation improve retention added GAA after immersion in water on growth performance Pangasius catfish (Pangasius hypophthalmus). juveniles with a mean body weight and length 16.05 ± 0.47 g 12.42 0.30 cm were randomly distributed into 9 pond units (2 x 1 0,6 m). Three experimental diets formulated contain...

BACKGROUND Mutations in the acid alpha-glucosidase (GAA) gene usually lead to reduced GAA activity. In this study, we analyzed the mutations of GAA and GAA enzyme activity from one sibling suspected Pompe disease and their first-degree relatives. MATERIALS AND METHODS In this cross-sectional study, GAA enzyme activity assay was assessed using tandem mass spectrometry. Polymerase chain reactio...

Introduction: Tunnel field effect transistors (TFET) have gained interest recently owing to their potential in achieving sub-kT/q steep switching slope, thus promising low Vcc operation[1-5]. Steep switching slope has already been demonstrated in Silicon TFET [2]. However, it has been theoretically shown and experimentally proved that Si or SixGe1-x based homo-junction or hetero-junction TFETs ...

This paper reports the performance of an epitaxial layer (ETL) based gate modulated (GM-TFET) through 3D Technology Computer Aided Design (TCAD) simulations. The architecture utilizes effects both vertical tunneling and lateral phenomena to improve device performance. Attributes ETL, its thickness (tepi) doping concentration (Nepi) are varied their impact on electrical parameters such as transf...

This study evaluates the effects of different levels of guanidinoacetic acid (GAA) supplement on growth performance and gut morphology in broilers (Ross 308 strain) raised at high altitude (2100 m). A total of 300 one-day-old male broiler chicks (Ross 308 strain) were used in a completely randomized design with five treatments and four replicate pens of 15 birds in each. Five dietary treatments...