The pathogenesis of spondyloarthritis (SpA) is multifactorial and involves multiple immune cells cytokines that are signaled by Janus kinase (JAK). Inhibition JAK signaling pathways has emerged as a new therapeutic option for patients with inflammatory joint diseases. Despite the proven effect treatment anti-IL-17, well TNFα inhibitors, some ankylosing spondylitis cannot reach minimal disease a...

Introduction: Microglia, small glial cells, i.e. mesodermal in origin and found in the brain and spinal cord, play a key role in the maintenance of neurons and immune defense. Haloperidol, an antipsychotic drug, is used to treat numerous neurological and neurodegenerative disorders. Its mechanism is not understood; however, haloperidol may result in Wnt signaling pathway activation. This study ...

The importance of dissecting signaling pathways governing cell differentiation is based on their relevance not only for understanding basic biological phenomena but also better comprehending the underlying mechanisms pathologic alterations such as cancer. A paradigm processes hematopoiesis, where a single stem gives rise to multiple, fully differentiated, lineages. Nucleoredoxin (Nrx), member t...

The therapeutic effect of combined drugs on cervical cancer has been confirmed. Whether antiprogrammed cell death protein 1 antibody with paclitaxel mediates the phosphoinositide 3-kinase-protein kinase B pathway to regulate still needs further research. 20 nude mice received subcutaneous administration Henrietta Lacks cells establish model which was then assigned into blank control group, grou...

Abstract Long non-coding RNAs (lncRNAs) regulate numerous physiological processes and the etiology of diseases including cancers. However, lncRNA-based therapies are limited because mechanism action many lncRNAs their interaction with binding partners is not completely understood. We have identified LINC02283, a novel oncogenic lncRNA, highly expressed in PDGF Receptor A (PDGFRA)-mutation drive...

Objective Bacterial and viral infectious triggers are linked to spondyloarthritis (SpA) including psoriatic arthritis (PsA) development, likely via dendritic cell activation. We investigated spinal entheseal plasmacytoid cells (pDCs) toll-like receptor (TLR)-7 9 activation therapeutic modulation, JAK inhibition. also if COVID-19 infection, a potent TLR-7 stimulator triggered PsA flares. Methods...

Notch-mediated lateral inhibition regulates binary cell fate choice, resulting in salt and pepper patterns during various developmental processes. However, how Notch signaling behaves in combination with other signaling systems remains elusive. The wave of differentiation in the Drosophila visual center or "proneural wave" accompanies Notch activity that is propagated without the formation of a...

in the present study the distribution of rubella hemagglutination inhibition (hi) antibody titer in the sera of 1486 women of 18 to 25 years old residing in tehran were examined. sera were pretreated with acid washed kaolin and pigeon red blood cell. titers below 1:10 and in some studies below 1:20 are considered nonimmune to rubella. our results show that 10, 29% of studied population had hi a...

BRs (Brassinosteroids) regulate many essential pathways related to growth, cell elongation, expansion, plant architecture, and fruit development. The potential exogenous application of BR-derivatives has been proven stimulate growth development, including quality attributes fruits, whereas its biosynthesis inhibition shown the opposite effect. In this study, BR-insensitive tomato mutants were u...