objective: tabernaemontana divaricata (td) from apocynaceae family offers the traditional folklore medicinal benefits such as an anti-epileptic, anti-mania, brain tonic, and anti-oxidant. the aim of the present study was to evaluate the effect of ethanolic extract of td leaves on burying behavior in mice. materials and methods:mice were treated with oral administration (p.o.) of ethanolic extra...

The regulation of dopamine and serotonin synthesis in rat brain striatal synaptosomes has been studied using HPLC methods. Noradrenaline was shown to markedly inhibit both the synthesis of dopamine and serotonin. The response of the synaptosomes to the concentrations of noradrenaline appeared to be biphasic, a very effective inhibition occurring at low concentrations (1-5 µm) and a relativ...

The impacts of antidepressants on the pathogenesis of dementia remain unclear despite depression and dementia are closely related. Antidepressants have been reported may impair serotonin-regulated adaptive processes, increase neurological side-effects and cytotoxicity. An 'astroglio-centric' perspective of neurodegenerative diseases proposes astrocyte dysfunction is involved in the impairment o...

Trazodone is a selective antagonist and serotonin reuptake inhibitor used in medicine to treat anxiety. Toxicological studies of trazodone succinate were carried out on the basis Department Pharmacology Veterinary Faculty Stavropol State Agrarian University, Russia.
 The results obtained study acute toxicity drug Express Uspokoin® tablets allow us identify new as belonging moderately dange...

Volume 23, Issue 9 June 2008 1 Major depressive disorder (MDD) is characterized as a disabling psychiatric disorder, presenting with a loss of pleasure and interest in activities that normally bring satisfaction and enjoyment. MDD is a common disorder, roughly occurring at least once in the lifetime of 16.2% of US adults (32.6-35.1 million people), and at least once in the past year of 6.6% of ...

BACKGROUND Although several studies show that there is an increased risk of bleeding events during antidepressant treatment with selective serotonin reuptake inhibitors (SSRIs), few studies show direct effects in vitro of SSRIs on hemostasis. METHODS This study was undertaken to investigate the effects on platelet adhesion and plasma coagulation (APTT and PT) of two common SSRIs, citalopram a...