The eukaryotic RNA exosome participates extensively in RNA processing and degradation. In human cells, three accessory factors (RBM7, ZCCHC8 and hMTR4) interact to form the nuclear exosome targeting (NEXT) complex, which directs a subset of non-coding RNAs for exosomal degradation. Here we elucidate how RBM7 is incorporated in the NEXT complex. We identify a proline-rich segment of ZCCHC8 as th...

In the automotive industry, the knowledge, information, and tools required for design, analysis, manufacturing, and testing of company products are distributed throughout the organization. This fragmentation of expertise and information creates impediments to cost-eeective design engineering. This article describes: 1) an approach to building integrated engineering environments based on blackbo...

In this paper we describe analysis of longitudinal substance use outcomes using random-effects regression models (RRM). Some of the advantages of this approach is that these models allow for incomplete data across time, time-invariant and time-varying covariates, and can estimate individual change across time. Because substance use outcomes are often measured in terms of dichotomous or ordinal ...

The objective of this study was to investigate genetic evaluations for final score (PTAT) at different ages. Breeding values were predicted with a random regression model (RRM) and with the current national genetic evaluation model (NE), a repeatability model. RRM included fixed effects for management group and stage of lactation; fixed regressions on age at classification; additive genetic and...

Abstract. In this paper we develop a novel framework aimed to significantly reduce biases related marine stratocumulus clouds in general circulation models (GCMs) while circumventing excessive computational cost requirements. Our strategy is increase the horizontal resolution using regionally refined mesh (RRM) over our region of interest addition Framework for Improvement by Vertical Enhanceme...

Cognitive radio (CR) paradigm was introduced, towards addressing challenges, related with radio spectrum scarcity and increased needs for wireless networking services provision. In this direction, CR networks exploit novel networking architectures, as well as dynamic radio spectrum access techniques and methods, alleviating problems, regarding limited wireless networking resources and their ine...

The opportunistic beamforming (OB) technique in multicellular OFDMA networks is investigated in this paper. Three cross-layer radio resource management (RRM) algorithms for OFDMA operational scenarios are considered. These algorithms build upon typical network planning practices for OFDMA systems. The first two implement an OFDMA network with opportunistic rate adaptation while the third one ai...

We present a systematic analysis of sequence motifs found in metazoan protein factors involved in constitutive pre-mRNA splicing and in alternative splicing regulation. Using profile analysis we constructed a database enriched in protein sequences containing one or more presumptive copies of the RNA-recognition motif (RRM). We provide an accurate alignment of RRMs and structure-based criteria f...

The present study evaluated the contribution of cytochrome P-450 omega-hydroxylase in modulating the reactivity of cremaster muscle arterioles in normotensive rats on high-salt (HS) and low-salt (LS) diet and in rats with reduced renal mass hypertension (RRM-HT). Changes in arteriolar diameter in response to ACh, sodium nitroprusside (SNP), ANG II, and elevated O(2) were measured via television...

The heterogeneity in cellular networks that comprise multiple base stations’ types imposes new challenges in network planning and deployment. The Radio Resource Management (RRM) techniques, such as dynamic sharing of the available resources and advanced user association strategies determine the overall network capacity and the network/spectrum efficiency. This paper evaluates the downlink perfo...