Multiple studies have shown that the progression of breast cancer depends on multiple signaling pathways, suggesting therapies with multitargeted anticancer agents will offer improved therapeutic benefits through synergistic effects in inhibiting growth. Dual-targeted inhibitors phosphoinositide 3-kinase (PI3-K) and histone deacetylase (HDAC) emerged as promising therapy candidates. However, po...

Oligomer Coupling Agents in Phosphate Based Glass Fibre/PLA Composites P Haque, AJ Parsons, I Ahmed, DJ Irvine, GS Walker, CD Rudd (Univ of Nottingham) Polylactic acid oligomers as coupling agents have showed potentially higher interfacial shear strength in phosphate based glass fibre/ PLA composites. To influence bonding on the glass fibre surface, the short chain PLA with different end groups...

polylactic acid based biodegradable nanocomposites reinforced with acetylated nanocellulose were fabricated with solution casting procedure. the nanocomposites were prepared by adding 1, 3 and 5% nanofiber loadings. the microstructure, physical, mechanical and thermal properties of the prepared nanocomposites were investigated. scanning electronic microscope (sem) analysis of the composites con...

Polylactic acid (PLA) was successfully covalently grafted onto multi-walled carbon nanotubes (MWCNT) by microwave-assisted polymerization of lactide monomers. The final products MWCNT-g-PLA were characterized with Fourier-transform IR (FTIR), Raman spectroscopy, thermogravimetric analyses (TGA) and transmission electron microscopy (TEM). The results indicated PLA chain was covalently attached t...

In natural world, lignin is unique and the most abundant renewable carbon source after cellulose, therefore, more applications of adding commercial value of lignin are needed. Polylactic acid (PLA), which has the second highest consumption of bioplastic in the world, is a biodegradable composite with widely application in industry. A filler adding into PLA can decrease the cost of the composite...

PURPOSE To investigate the possibility of using polylactic acid (PLA) as a surgical adjuvant for visualizing the vitreous body during vitrectomy. METHODS After a core vitrectomy, 1 mL of PLA suspension was injected into the rabbit vitreous in two groups: group A, 2.5% PLA (n = 5), and group B, 1% PLA (n = 9). Vehicle injection instead of PLA was used as a control (group C, n = 5). The clinica...

RATIONALE Isoniazid given daily for 9 months is the standard treatment for latent tuberculosis infection (LTBI), but its effectiveness is limited by poor completion rates. Shorter course regimens and regimens using directly observed therapy result in improved adherence but have higher upfront costs. OBJECTIVES To evaluate the costs and cost-effectiveness of regimens for the treatment of LTBI....

The cover image is based on the Review Opportunities and Challenges of Establishing a Regional Bio-based Polylactic Acid Supply Chain by Ali Abdelshafy et al., https://doi.org/10.1002/gch2.202200218 Image Credit: Sonja Herres-Pawlis.

The eye is a well-suited organ for local delivery of therapeutics to treat vitreous inflammation as well as other pathologic conditions that induce visual loss. Several conditions are particularly challenging to treat and often require chronic courses of therapy. The use of implantable intravitreal devices for drug delivery is an emerging field in the treatment of vitreous inflammation as well ...