The direct reprogramming of fibroblasts into functional cardiac myocytes is expected to bring new cell therapies for heart failure. Already, essential transcription factors for the reprogramming have been identified. However, several obstacles must be overcome before this technology benefits patients. In particular, there is a need to improve the efficiency of the reprogramming, especially with...

In this paper I have given a mathematical model of Cell reprogramming from a different contexts. Here I considered there is a delay in differential regulator rate equations due to intermediate regulator’s regulations. At first I gave some basic mathematical models by Ferell Jr.[2] of reprogramming and after that I gave mathematical model of cell reprogramming by Mithun Mitra[4]. In the last sec...

Building adaptive WSN applications through reprogramming is a fantastic area. Recent research in wireless sensor networks (WSNs) has highlighted the importance of supporting the capability for remote reprogramming of sensor nodes via wireless network. Ease of programming has long been recognized as a major hurdle to the adoption of WSN technology. There are lots of key issue & open problems tha...

Molecular insights into somatic cell reprogramming to induced pluripotent stem cells (iPS) would aid regenerative medicine, but are difficult to elucidate in iPS because of their heterogeneity, as relatively few cells undergo reprogramming (0.1–1%; refs 1,2). To identify early acting regulators, we capitalized on non-dividing heterokaryons (mouse embryonic stem cells fused to human fibroblasts)...

A novel secure and distributed reprogramming protocol called SDRP is the prime distributed reprogramming protocol for Wireless Sensor Networks (WSNs). SDRP relies on distributed reprogramming approach that permits multiple authorized network users to directly and simultaneously update program images on different sensor nodes without including the base station. SDRP expands Deluge to be a secure...

Direct lineage reprogramming represents a remarkable conversion of cellular and transcriptome states. However, the intermediate stages through which individual cells progress during reprogramming are largely undefined. Here we use single-cell RNA sequencing at multiple time points to dissect direct reprogramming from mouse embryonic fibroblasts to induced neuronal cells. By deconstructing heter...

Differentiated cells can be reprogrammed to the pluripotent state by overexpression of defined factors, and this process is profoundly influenced by epigenetic mechanisms including dynamic histone modifications. Changes in H3K4 methylation have been shown to be the predominant activating response in the early stage of cellular reprogramming. Mechanisms underlying such epigenetic priming, howeve...

Nuclear reprogramming, the conversion of the epigenome of a differentiated cell to one that is similar to the undifferentiated embryonic state, can be facilitated by several methods, such as nuclear transfer, cell fusion, use of embryonic stem cell extracts, and more recently, by the introduction of exogenous transcription factors. Amongst these various strategies, somatic cell nuclear transfer...

Transplantation of Xenopus laevis cell nucleus to enucleated Xenopus egg leads to the generation of cloned animal. This exemplifies the process of nuclear reprogramming by which the nucleus of a specialized cell is reset to an embryonic state from which it can generate all the cells of an organism. Using the precursor of the egg, the oocyte, it is also possible to reprogram somatic cell. The ad...