Aim To evaluate the effect of red wine consumption or its polyphenols on inflammation/resorption processes associated with apical periodontitis in rats. Methodology Thirty-two three-month-old Wistar rats had induced four first molars and were then arranged into groups: control (C)—rats periodontitis; (W)—rats receiving 4.28 ml/kg wine; resveratrol+quercetin (R+Q)—rats a solution containing 1.00...

The purpose of this study was to determine and compare the Vertebral Heart Size (VHS) Cardio-Thoracic Rate (CTR) in normal Wistar Rats. size organs chest cavity heart can be measured by taking thorax radiographs. Thorax radiographs 85 male rats were taken under anesthesia, VHS CTR calculated digital environment. mean 7.22 mm right lateral position 7.34 left position. In radiography ventrodorsal...

objectives: crocin and safranal, the major constituents of saffron, exert neuroprotective effects. in the present study, we investigated the effects of crocin and safranal  (alone or in combination with insulin) on peripheral neuropathy in diabetic rats. materials and methods: diabetes was induced by intraperitoneal (i.p.) injection of 60 mg/kg of streptozotocin (stz) and confirmed by blood glu...

background: it has been known that brain-derived neurotrophic factor (bdnf) is involved in neural survival and long term memory (ltm). here we hypothesized that bdnf as a potent neurotrophic factor might modulate amnestic effect induced by morphine. objectives: the aim of this study was to examine whether infusion of exogenous bdnf in the ca1 regions of the dorsal hippocampi could ameliorate me...

introduction: the use of lopinavir/ritonavir (lpv/r) has decreased morbidity and mortality due to human immunodeficiency virus (hiv); however its use could be impaired by hepatotoxicity. therefore, this study was designed to investigate the effects of melatonin (mt) and alpha lipoic acid (ala) on lpv/r-induced hepatotoxicity in male albino rats. methods: rats were divided into groups and treate...

teucrium polium l. (tp) is widely used in traditional medicine of many countries including iran. there are various reports about pharmacological properties of tp such as calcium antagonist, anti- ulcer, anti – diabetic. there are a few reports about possible toxicological effects of this plant. in the present study we designed to evaluate the subchronic toxicity of teucrium polium total extract...

background: iron is an essential mineral for normal cellular physiology but its ‎overload can lead to cell injury. for many years, deferoxamine injection has been used ‎as an iron chelator for treatment of iron overload. the aim of this study is to compare ‎oral deferoxamine, activated charcoal, and vitamin c, as an absorbent factor of fe, in ‎changing the serum level of iron in iron overload r...

objective(s) this study was conducted to evaluate the effects of niacin on glucocorticoid-induced dyslipidemia and fatty liver in rats. materials and methods twenty four adult male rats were divided randomly into four equal groups: 1- normal saline (control), 2- dexamathasone 0.125 mg/kg/day, i.m., 3- dexamathasone + niacin 200 mg/kg/day, oral gavages, 4- niacin. after 2 weeks, serum total chol...

objective(s) ocimum basilicum l. is widely used in folk medicine of many countries including iran. both o. basilicum and its oil extract have received considerable attention for their potential medicinal properties, but there are a few reports about possible toxicity of this plant. therefore, in the present study, acute and subchronic toxicity of o. basilicum hydroalcohlic extract have been eva...