Imaging biomarkers define objective characteristics extracted from medical images that are related to normal biological processes, diseases, or the response to treatment. To develop an imaging biomarker, it is necessary to carry out a series of steps to validate its relation with the reality studied and to check its clinical and technical validity. This process includes defining tests for the c...

The luminance nonlinearity introduced by many imaging devices can often be described by a simple point-wise operation (gamma correction). This paper presents a technique for blindly estimating the amount of gamma correction in the absence of any calibration information or knowledge of the imaging device. The basic approach exploits the fact that gamma correction introduces specific higher-order...

Colchicine as a vascular disrupting agent creates microtubule destabilization whichinduces vessel blockage and consequently cell death. Accordingly, colchicines and itsanalogues radiolabeled with 99mTc may have potential for visualization of tumor. In this work,deacetylcolchicine a colchicine analogue was labeled with 99mTc via tricine as a coligandand characterized for its tumor targeting prop...

Introduction: Nuclear medicine techniques have been widely employed in the assessment of gastroesophageal dysfunction. Gastroesophageal reflux (GER) is a common, self-limited process in infants and children that usually resolves at 12 to 18 months of age. Clinical management of GER includes conservative treatment, thickened feedings, positional therapy and parental reassurance. On the other han...

introduction: despite widespread use of 67gallium for lymphoma evaluation, timing of imaging after injection is a matter of controversy and to the extent of our knowledge no direct comparison has been made between early and delayed gallium images. we aimed to compare 24 and 48 hours post injection planar gallium imaging for evaluation of lymphoma recurrence. methods: 255 patients suspicious of...

introduction:myocardial 18f-fdg uptake is highly variable in oncologic whole body 18f-fdg pet/ct studies, ranging from quite intense to minimal distribution. intense or heterogeneous myocardial 18f-fdg uptake is undesirable as it may interfere with the visual or quantitative evaluation of tumoral invasion and metastases in pericardium, myocardium or adjacent mediastinal structures. the diet, as...

In conventional Compton camera systems, the image reconstruction is performed only in two-dimensional or three-dimensional spatial coordinates for a specific gamma-ray energy. By doing so, a priori knowledge of the incident gamma-ray energy is required, and usually an energy window is applied to select full energy deposition events. In some other applications, spectral-deconvolution algorithms ...

As MRI threatens the use of bone scintigraphy for skeletal metastases and 18F-fluorodeoxyglucose positron emission tomography (18FDG-PET) emerges as the main focus in nuclear oncology, the future role of the gamma camera in cancer imaging appears unclear. However, there is a range of pre-existing conventional gamma camera techniques that have incremental benefit over CT and other structural ima...