نتایج جستجو برای: q23
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A 65-year old woman with dyspnea, headaches, and epistaxis presented anemia (hemoglobin 7.7 g/dL) thrombocytopenia (platelets 18×109/L) a white blood cell (WBC) count of 4.0 × 109/L 60% circulating blasts. Bone marrow blast percentage was 95%, blasts were small to intermediate in size reticulated chromatin scant cytoplasm on bone aspirate (Figure 1, panel A, original magnification 1000×, Wright...
which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Molecular methods for genomic analyses of variant PML-RARA or other RARA-related chromo-somal translocations in acute promyelocytic leukemia TO THE EDITOR: We read an interesting paper by Palta et al. in a recent issue of the Korean Journal of Hematology tit...
Nonrandom recurrent chromosomal abnormalities are ubiquitous in multiple myeloma (MM) and include, among others, translocations of the immunoglobulin heavy chain locus (IgH). IgH translocations in MM result in the up-regulation of oncogenes, and include more commonly t(11;14)(q13;q32), t(4;14)(p16;q32), and t(14;16)(q32;q23). Based on the recurrent nature of these translocations and their findi...
Anaplastic lymphoma kinase (ALK)-positive diffuse large B cell lymphoma (DLBCL) with expression of CD38 and lack of CD30 was first described in 1997. With few exceptions these ALK-positive DLBCL show a fine granular cytoplasmic ALK-staining characteristic for the fusion of CLTC with ALK caused by the reciprocal translocation t(2;17)(p23;q23). This rare but characteristic lymphoma subtype is ass...
We present the case of a patient with MDS RARS subtype with loss of part of the long arm of chromosome 11 del 11(q23). This a cytogenetic abnormality that occurs in 7% to 20% of RARS cases not related to poor prognosis. It seems that this deletion is a marker of iron overload in MDS.
Temozolomide (TMZ), an alkylating agent, is widely used for treating high-grade gliomas. TMZ has been reported to cause secondary myelodysplastic syndrome and acute myeloid leukemia. However, TMZ-related acute lymphoblastic leukemia is rare. Here we describe a 54-year-old woman with glioblastoma multiforme, who developed precursor-B acute lymphoblastic leukemia with translocation (4;11)(q21;q23...
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