Recent reports have suggested an association between Helicobacter pylori infection and both gastric mucosa associated lymphoid tissue (MALT) lymphoma and thrombocytopenic purpura. Although treatments eradicating H pylori lead to regression of these diseases in some cases, the exact mechanisms are still controversial. This case report describes a patient with thrombocytopenic purpura accompanied...

Asplenic patients are at increased risk for sepsis and fulminant infection. Sepsis in these patients is typically secondary to encapsulated bacteria, with Streptococcus pneumoniae being the most frequent pathogen. Rare complications of severe sepsis include purpura fulminans and bilateral adrenal hemorrhage (Waterhouse-Friderichsen syndrome). We present the case of a 36-year-old woman, healthy ...

We have substantial concerns about the final input parameters in cost-effectiveness analysis by Sanofi that was used to support National Institute for Health and Care Excellence (NICE) recommendation caplacizumab acute acquired thrombotic thrombocytopenic purpura, 1 ExcellenceTechnology appraisal guidance TA667: with plasma exchange immunosuppression treating purpura. https://www.nice.org.uk/gu...

Vasculitis has protean manifestations with etiological non-specificity of histological lesions. The natural history of Henoch-Schönlein purpura in adults is less well established. We report an adult female patient who presented with palpable skin purpura and was evaluated to have IgA nephritis who remains stable on treatment with cyclophosphamide and steroids.

Henoch-Schönlein purpura is a small vessel vasculitis with multi-system manifestations that commonly affects children. We describe a case of new onset Henoch-Schönlein purpura in a previously healthy 42-year-old female who required an emergency laparotomy for small bowel perforation.

A 19-year-old woman presented with purpura fulminans and septic shock; subsequently, progressive coagulopathy, widespread purpura fulminans associated with meningococcemia, severe shock, respiratory, and renal failure developed. This clinical course was associated with depletion of functional protein C levels to < 5%. We describe her clinical course and therapy with human recombinant activated ...

A 19 years male presented with fever, oliguria and purpuric lesions involving both hands. The patient was diagnosed as a case of purpura fulminans with disseminated intravascular coagulation due to complicated falciparum malaria. The case is presented to sensitize the physicians to keep malaria as a differential in cases of fever with purpura fulminans.

Henoch-Shönlein purpura (HSP) is an acute, self-limited, systemic, small vessel vasculitis, that induces skin lesions, arthritis and abdominal pain. Palpable purpura is the most common manifestation in pediatric patients with HSP. We present an atypical case of HSP in a young patient and report successful treatment of the atypical skin lesions, while avoiding surgery.

We present a case of vascular purpura revealing an intra-cardiac left-sided thrombus complicating an end-stage dilated cardiomyopathy. Vascular purpura main etiologies encompass the wide specturm of vasculitides and microvascular-occlusion syndromes. Among them, cardiac embolism represents an unusal but potentially severe etology.

Un homme de 49 ans est hospitalisé pour un purpura vasculaire évoluant depuis 5 jours, associé à des douleurs abdominales maximales au niveau de l'hypochondre droit. A l'examen physique on note un purpura generalisé (A,B), ainsi qu'une sensibilité abdominale diffuse. Au bilan biologique, l'hémogramme montre une hyperleucocytose à polynucléaires neutrophiles sans atteinte des autres lignées, on ...