The objectives of this study were to assess the feasibility of low flow right ventricular support and to describe the hemodynamic effects of low versus high flow support in an animal model of acute right ventricular pressure overload. A Synergy Pocket Micro-pump (HeartWare International, Framingham, MA) was implanted in seven sheep. Blood was withdrawn from the right atrium to the pulmonary art...

BACKGROUND Alveolar hypoxia induces monophasic pulmonary vasoconstriction in vivo, biphasic vasoconstriction in the isolated pulmonary artery, and controversial responses in the isolated perfused lung. Pulmonary vascular responses to sustained alveolar hypoxia have not been addressed in the isolated perfused rat lung. In this study, we investigated the effect of sustained hypoxic ventilation on...

Methods We included 139 patients undergoing CMR and right heart catheterization within 2 days (n=151 test pairs) for the evaluation of known or suspected pulmonary hypertension. Right ventricular end-systolic volume index (ESVI) and stroke volume index (SVI) were obtained, respectively, from cardiac cine images and phasecontrast of the pulmonary artery after adjusting for body surface area. Rig...

Twenty-one patients, 11 with normal pulomonary artery pressures and 10 with pulmonary hypertension, had haemodynamic measurements performed before and during dopamine infusion while undergoing cardiac catheterization, in order to evaluate the circulatory effects of dopamine in pulmonary hypertension. In both groups on average, heart rate, pulmonary artery mean pressure, aortic mean pressure, a...

In 82 patients with acute myocardial infarction, observed haemodynamic changes were compared with the average maximal serum enzyme rise and the infarct size, as calculated from serial determinations of creatine phosphokinase concentration. For this purpose, patients were divided into 3 groups according to their pulmonary artery end-diastolic pressure at the time of admission. There were I9 pati...

BACKGROUND In patients with heart failure, pulmonary hypertension (PH) predicts higher risk for morbidity and mortality. However, few data are available on the prognostic implications of reactive (precapillary) PH superimposed on passive (postcapillary) PH. METHODS AND RESULTS We performed a subgroup analysis of 242 patients with acute decompensated heart failure assigned to pulmonary artery ...

OBJECTIVE The state of pulmonary vascular bed in congenital heart disease is the predictor of the patients clinical condition, prognosis and outcome of surgical intervention. This study aims to investigate the condition of pulmonary vascular bed analyzing pulmonary artery stiffness by means of Doppler echocardiography. METHODS Thirty-three patients (16 females, mean age 26+/-15 years) with va...