Acetylcholinesterase (AChE) is responsible for the hydrolysis of the neurotransmitter, acetylcholine, in the nervous system. The functional localization and oligomerization of AChE T variant are depending primarily on the association of their anchoring partners, either collagen tail (ColQ) or proline-rich membrane anchor (PRiMA). Complexes with ColQ represent the asymmetric forms (A(12)) in mus...

The perl language is a powerful tool for creation of portable programs on a wide range of platforms. Support of the graphic user interface is not included in perl, and is provided by several stand-alone graphical toolkits. The most popular modules are Perl-Tk and Wx, based on multi-platform libraries, correspondingly Tcl-Tk and wxWindows, both written in C. The toolkit Prima was written to prov...

1. Overview In the following we wish to highlight the design and implementation concepts of a non-standard database system (NDBS) called PRIMA and its provision for object orientation. Non-standard database applications such as CAD/CAM, VLSI design, and knowledge-based systems require adequate modeling facilities for their application objects for various reasons [H~.88b]. Data models dedicated ...

Computational grids and other heterogeneous, large-scale distributed systems require more powerful and more flexible authorization mechanisms to realize fine-grained access-control of resources. Computational grids are increasingly used for collaborative problem-solving and advanced science and engineering applications. Usage scenarios for advanced grids require support for small, dynamic worki...

Mesotoga strain PhosAc3 was the first mesophilic cultivated member of the order Thermotogales. This genus currently contain two described species, M. prima and M. infera. Strain PhosAc3, isolated from a Tunisian digestor treating phosphogypsum, is phylogenetically closely related to M. prima strain MesG1.Ag.4.2(T). Strain PhosAc3 has a genome of 3.1 Mb with a G+C content of 45.2%. It contains 3...

Early Cambrian Pseudooides prima has been described from embryonic and post-embryonic stages of development, exhibiting long germ-band development. There has been some debate about the pattern of segmentation, but this interpretation, as among the earliest records of ecdysozoans, has been generally accepted. Here, we show that the 'germ band' of P. prima embryos separates along its mid axis dur...