Background Childhood obesity has increased as a health problem worldwide and WHO have declared that obesity is a global epidemic problem which is needed to be managed promptly. In the last decades, prevalence of childhood obesity has raised dramatically. Childhood obesity may results in overweight and impose other health problems. It is also a risk factor for development of Type-2 Diabetes Mell...

BACKGROUND Few data are available on the association of variables of the insulin resistance syndrome and serum ferritin, an indicator of body iron stores. We examined the relationship between serum ferritin levels and impaired fasting glucose, a pre-diabetes stage associated with insulin resistance, in this study. SUBJECTS & METHODS One hundred and eighty seven people, including 91 subjects w...

OBJECTIVE Muscle carnosine and its methylated form anserine are histidine-containing dipeptides. Both dipeptides have the ability to quench reactive carbonyl species and previous studies have shown that endogenous tissue levels are decreased in chronic diseases, such as diabetes. DESIGN AND METHODS Rodent study: Skeletal muscles of rats and mice were collected from 4 different diet-interventi...

Recently, a model was proposed to assess hepatic insulin sensitivity during a meal, i.e., the ability of insulin to suppress glucose production (EGP), SI (P). The model was developed on EGP data obtained from a triple-tracer meal and the tracer-to-tracee clamp technique and validated against the euglycemic hyperinsulinemic clamp. The aim of this study was to assess whether SI (P) can be obtaine...

BACKGROUND Insulin is a stimulator of skeletal muscle protein anabolism and insulin resistance might therefore negatively affect muscle protein metabolism. We investigated muscle mass and physical function before and after a resistance exercise program in participants with prediabetes or type 2 diabetes mellitus (T2DM) in comparison to healthy controls. METHODS This was a secondary analysis o...

OBJECTIVES This study aims to increase understanding of the connection between oxidative stress and inflammation in diabetes disease progression to provide a basis for investigating improved diagnostic possibilities, treatment and prevention of prediabetes. DESIGN AND METHODS Differences in the level of biochemical markers of oxidative stress (erythrocyte GSH/GSSG and urinary 8-isoprostane), ...

BACKGROUND A decrease in the compliance of the arterial system, termed arterial stiffness, results in increased cardiac workload. Several studies have shown that arterial stiffness is increased in individuals with type 2 diabetes. Also, insulin resistance is generally considered to be of major importance in the pathophysiology of type 2 diabetes mellitus given that glucose intolerance and insul...

Burnham, Matthew P., Ian T. Johnson, and Arthur H. Weston. Reduced Ca -dependent activation of large-conductance Ca -activated K channels from arteries of Type 2 diabetic Zucker diabetic fatty rats. Am J Physiol Heart Circ Physiol 290: H1520–H1527, 2006. First published November 4, 2005; doi:10.1152/ajpheart.00827.2005.—Although it is well established that diabetes impairs endotheliumdependent ...