BACKGROUND The United States Advisory Committee on Immunization Practices recommends administration of the 13-valent pneumococcal conjugate vaccine in series with the 23-valent pneumococcal polysaccharide vaccine for prevention of pneumonia in the elderly. Reports of autoimmune or auto-inflammatory diseases as a result of pneumococcal vaccination, especially pneumococcal conjugate vaccine, are ...

Introduction. Streptococcus pneumoniae is the most common pathogen causing respiratory tract infections and invasive infections. In 2012 and 2013 we observed an increased incidence of drug-resistant SP in patients treated in Pediatric Hospital of Warsaw Medical University. Aim. To evaluate the pneumococcal infections and the susceptibility to antibiotics. To examine the correlation between the ...

Streptococcus pneumoniae is the leading cause of respiratory infection worldwide. Although oral hygiene has been considered a risk factor for developing pneumonia, the relationship between oral bacteria and pneumococcal infection is unknown. In this study, we examined the synergic effects of Prevotella intermedia, a major periodontopathic bacterium, on pneumococcal pneumonia. The synergic effec...

1Senior Consultant, Institute of Infectious Diseases, Apollo Hospitals, Chennai; Adjunct Professor, Tamil Nadu Dr. MGR Medical University; Adjunct Associate Professor, Apollo Hospitals Educational and Research Foundation. S v e r e a n d r e c u r r e n t pneumococcal disease is more common with HIV infect ion. 13 Adults infected with human immunodeficiency virus (HIV) are at high risk for Stre...

BACKGROUND Streptococcus pneumoniae is a major cause of morbidity and mortality worldwide, but also a common colonizer of the upper respiratory tract. The emergence and spread of antibiotic resistant pneumococcal strains has threatened effective therapy. The long-term effects of measures aiming to limit pneumococcal spread are poorly understood. Computational modeling makes it possible to condu...

Pneumococcal polysaccharide-based vaccines are effective in preventing pneumococcus infection; however, some drawbacks preclude their widespread use in developing and undeveloped countries. Here, we evaluated the protective effects of ATP-dependent caseinolytic protease (ClpP), pneumolysin mutant (DeltaA146 Ply), putative lipoate-protein ligase (Lpl), or combinations thereof against pneumococca...

Immunization of pregnant women can be an efficient strategy to induce early protection in infants in developing countries. Pneumococcal protein-based vaccines may have the capacity to induce pneumococcal serotype-independent protection. To understand the potential of maternal pneumococcal protein-specific antibodies in infants in high-risk areas, we studied the placental transfer of naturally a...

OBJECTIVE To investigate whether passive cigarette smoke exposure increases the risk of invasive pneumococcal disease in children. METHODS In a population-based case-control study, 171 children aged 0 to 12 years with culture-confirmed invasive pneumococcal disease during the years 1994 to 2004 were identified. Two controls were matched to each case on age and patterns of Health Plan membersh...

Dear Sir: We read with great interest the article on pneumococcal serotyping in Laos by Moore and others 1 and the accompanying editorial by Mehta 2 in the September 2010 issue of The American Journal of Tropical Medicine and Hygiene. We commend Moore on describing the pneumococcal serotype distribution in this country in Asia, a region with relatively few data on pneumococcal serotypes causing...

INTRODUCTION Streptococcus pneumoniae is a major cause of morbidity and mortality. We sought to describe the epidemiology of non-invasive and invasive pneumococcal disease in a national Veterans Affairs population within the United States. METHODS We conducted a retrospective study in older patients (aged ≥50 years) with positive pneumococcal cultures from any site between 2002 and 2011. We d...