نتایج جستجو برای: plc gene

تعداد نتایج: 1146437  

Journal: :Cellular signalling 2008
Shu-Ju Chang Chii-Ruey Tzeng Yi-Hsuan Lee Chen-Jei Tai

ATP is an extracellular signaling molecule that activates specific G protein-coupled P2Y receptors in most cell types to mediate diverse biological effects. ATP has been shown to activate the phospholipase C (PLC)/diacylglycerol/protein kinase C (PKC) pathway in various systems. However, little is known about the signaling events in human endometrial stromal cells (hESCs). The objective of this...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1987
K Y Lee S H Ryu P G Suh W C Choi S G Rhee

We previously reported that cytosolic fractions of bovine brain contain two immunologically distinct phosphoinositide-specific phospholipases C (PLCs), PLC-I and PLC-II. In this report the subcellular distribution of PLC-I and PLC-II in brain homogenates was measured using RIA. Significant differences were found in the distribution of the two forms of PLC in 100,000 X g supernatants (cytosolic ...

2013
Jing-Fang Zhao Hong-Hu Chen David M. Ojcius Xin Zhao Dexter Sun Yu-Mei Ge Lin-Li Zheng Xu’ai Lin Lan-Juan Li Jie Yan

BACKGROUND Leptospira-induced macrophage death has been confirmed to play a crucial role in pathogenesis of leptospirosis, a worldwide zoonotic infectious disease. Intracellular free Ca(2+) concentration ([Ca(2+)]i) elevation induced by infection can cause cell death, but [Ca(2+)]i changes and high [Ca(2+)]i-induced death of macrophages due to infection of Leptospira have not been previously re...

2003
STEVEN DAVIES

• The Littlewoods Organisation plc and Freemans plc, November 1997; • National Express Group plc and Central Trains Limited, December 1997, (background reading: National Express Group plc and ScotRail Railways Limited, December 1997); • British Sky Broadcasting Group plc and Manchester United PLC, April 1999; and • CHC Helicopter Corporation and Helicopter Services Group ASA, January 2000 (back...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1989
M I Wahl S Nishibe P G Suh S G Rhee G Carpenter

Epidermal growth factor (EGF) rapidly stimulates the formation of inositol 1,4,5-trisphosphate in a variety of cell types. Previously we have found that in intact cells stimulation of phospholipase C (PLC) activity by EGF is correlated with the retention of increased amounts of PLC activity by a phosphotyrosine immunoaffinity matrix, suggesting that the EGF-receptor tyrosine kinase phosphorylat...

Journal: :The Journal of Experimental Medicine 1992
A T Ting L M Karnitz R A Schoon R T Abraham P J Leibson

Crosslinking of the low affinity immunoglobulin G (IgG) Fc receptor (Fc gamma R type III) on natural killer (NK) cells initiates antibody-dependent cellular cytotoxicity. During this process, Fc gamma R stimulation results in the rapid activation of phospholipase C (PLC), which hydrolyzes membrane phosphoinositides, generating inositol-1,4,5-trisphosphate and sn-1,2-diacylglycerol as second mes...

Journal: :Journal of experimental botany 2004
Lewis N Mills Lee Hunt Calum P Leckie Fiona L Aitken Mark Wentworth Martin R McAinsh Julie E Gray Alistair M Hetherington

Studies using stably transformed tobacco plants containing very low levels of PI-PLC in their guard cells show that this enzyme plays a role in the events associated with the inhibition of stomatal opening by ABA, but not in the cellular reactions that are responsible for ABA-induced stomatal closure. However, Commelina communis guard cells microinjected with the InsP3 antagonist, heparin, fail...

Journal: :The Journal of biological chemistry 2001
I Ishii B Friedman X Ye S Kawamura C McGiffert J J Contos M A Kingsbury G Zhang J H Brown J Chun

Sphingosine 1-phosphate (S1P) exerts diverse physiological actions by activating its cognate G protein-coupled receptors. Five S1P receptors have been identified in mammals: LP(B1)/EDG-1, LP(B2)/H218/AGR16/EDG-5, LP(B3)/EDG-3, LP(B4)/NRG-1/EDG-8, and LP(C1)/EDG-6. One of these receptors, LP(B1), has recently been shown to be essential for mouse embryonic development. Here we disrupted the lp(B3...

Journal: :The Keio journal of medicine 2005
Ming-Te Lin

In order to establish an immortalized granulosa cell line and to investigate the potential mechanisms of immortalized cell proliferation, simian virus (SV) 40 was used to infect porcine granulosa cells from small follicles (1-2 mm in diameter), and one colony was selected after four weeks of culture. The colony was digested with trypsin and the cells were cultured for more than 300 days (named ...

2014
Tomoaki Ando Wenbin Xiao Peisong Gao Siavash Namiranian Kenji Matsumoto Yoshiaki Tomimori Hong Hong Hirotaka Yamashita Miho Kimura Jun-ichi Kashiwakura Tissa R. Hata Kenji Izuhara Michael F. Gurish Axel Roers Nicholas M. Rafaels Kathleen C. Barnes Colin Jamora Yuko Kawakami Toshiaki Kawakami

Atopic dermatitis (AD) is a chronic inflammatory skin disease. Here, we show that phospholipase C-β3 (PLC-β3)-deficient mice spontaneously develop AD-like skin lesions and more severe allergen-induced dermatitis than wild-type mice. Mast cells were required for both AD models and remarkably increased in the skin of Plcb3(-/-) mice because of the increased Stat5 and reduced SHP-1 activities. Mas...

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