A new rapid, simple, sensitive, selective and accurate reversed-phase stability-indicating Ultra Performance Liquid Chromatography (RP-UPLC) technique was developed for the assay of Tolterodine Tartrate in pharmaceutical dosage form, human plasma and urine samples. The developed UPLC method is superior in technology to conventional HPLC with respect to speed, solvent consumption, resolution and...

During the last two decades, hydrophilic swellable polymers have been widely used to control the release of a drug from matrix tablet formulations. The increasing need for suitable polymers to achieve the desired drug release profile conducted the pharmaceutical research to widely screening a large variety of both synthetic and natural polymers which show drug release retarding ability. Because...

Roller compaction is a dry granulation technique used in the pharmaceutical industry, in which a powder formulation is compressed into a ‘ribbon’ compact between two counter rotating rolls. The ribbon is subsequently milled into granules of a desired size range. Whilst simple in principle, successful control of a roller compaction process is often difficult as it is multivariate in design. Furt...

In this paper, the problem of terahertz pulsed imaging and reconstruction is addressed. It is assumed that an incomplete (subsampled) three dimensional THz data set has been acquired and the aim is to recover all missing samples. A sparsity-inducing approach is proposed for this purpose. First, a simple interpolation is applied to incomplete noisy data. Then, we propose a spatio-temporal dictio...

BACKGROUND Azithromycin (AZM) is used in periodontal infections. The present study compared gingival crevicular fluid concentration of azithromycin of two pharmaceutical companies through the HPLC method. METHODS Two groups (n=15) of healthy volunteers participated in this study. The first group received an imported azithromycin (ImAZM) tablet (250 mg, PO) and the second group received an azi...

Mouth dissolving tablets (MDTs) have received ever-increasing demand during the last decade, and the field has become a rapidly growing area in the pharmaceutical industry. Upon introduction into the mouth, these tablets dissolve or disintegrate in the mouth in the absence of additional water for easy administration of active pharmaceutical ingredients. The popularity and usefulness of the form...

This paper describes a collaborative theoretical and experimental research effort to investigate both the atomization dynamics of non-Newtonian liquids as well as the performance of coaxial atomizers utilized in pharmaceutical tablet coating. In pharmaceutically relevant applications, the coating solutions being atomized are typically complex, non-Newtonian fluids which may contain polymers, su...

Background: The aim of this study was to analyze the cost ratio and percentage variations in different brands commonly prescribed anti-epileptic drugs available Indian pharmaceutical market.Methods: maximum minimum price each brand drug given rupees (INR) noted by using CIMS January April 2020 edition today June volume 1. variation for individual calculated. one bottle case 100 ml syrup 10 tabl...

The WHO biowaiver procedure for BCS Class II weak acids was evaluated by running two multisource IR ibuprofen drug products (Ibuprofen, 200 mg tablets, Tatchempharmpreparaty, Russia and Ibuprofen, 200 mg tablets, Biosintez, Russia) with current Marketing Authorizations (i.e. in vivo bioequivalent) through that procedure. Risks associated with excipients interaction and therapeutic index were co...

Patient acceptability of a medicinal product is a key aspect in the development and prescribing of medicines. Children and older adults differ in many aspects from the other age subsets of population and require particular considerations in medication acceptability. This review highlights the similarities and differences in these two age groups in relation to factors affecting acceptability of ...