نتایج جستجو برای: ph sensitive nanoparticles

تعداد نتایج: 539402  

2014
K. Akilandeswari P. Karpagam K. Amutha

Biosynthesised nanoparticles have wider applications in medical and pharmaceutical fields. In our study aims to synthesis silver nanoparticles using biological source Serratia marcescens. The nano particle synthesis was optimized with different pH of the culture medium and concentration of metal salts that affected the nanoparticles formation during synthesis. Culture medium with different pH s...

Journal: :Dalton transactions 2012
Chenguang Li Lei Xing Shunai Che

Zn-loaded bovine serum albumin nanoparticles (Zn-BSA nanoparticles) were prepared and used as carriers for pH-responsive anticancer drug delivery. Zinc was introduced into this system to increase the stability of the BSA nanoparticles and to load the anticancer drug based on the coordination bonding formation of Zn-BSA and Zn-drug molecules, respectively. The cleavage of either the "Zn-BSA" or ...

Journal: :biomacromolecular journal 2015
behafarid ghalandari adeleh divsalar ali komeili mahbube eslami-moghadam ali akbar saboury

to answer challenge of targeted and controlled drug release in oral delivery various materials were studied by different methods. in the present paper, controlled metal based drug (pd(ii) complex) release manner of β‑lactoglobulin (β-lg) nanoparticles was investigated using mathematical drug release model in order to design and production of a new oral drug delivery system for gastrointestinal ...

2013
Fei Wu Zhihua Zhou Jing Su Liangming Wei Weien Yuan Tuo Jin

One of the most challenging problems in the development of protein pharmaceuticals is to deal with stabilities of proteins due to its complicated structures. This study aims to develop a novel approach to stabilize and encapsulate proteins into dextran nanoparticles without contacting the interface between the aqueous phase and the organic phase. The bovine serum albumin, granulocyte-macrophage...

2012
Jae-Yoon Shin Yoosoo Yang Paul Heo Ji-Chun Lee ByoungJae Kong Jae Youl Cho Keejung Yoon Cheol-Su Shin Jin-Ho Seo Sung-Gun Kim Dae-Hyuk Kweon

BACKGROUND Nanoparticles undergoing physicochemical changes to release enclosed drugs at acidic pH conditions are promising vehicles for antitumor drug delivery. Among the various drug carriers, high-density lipoprotein (HDL)-like nanoparticles have been shown to be beneficial for cancer chemotherapy, but have not yet been designed to be pH-responsive. METHODS AND RESULTS In this study, we de...

2016
Shaoping Sun Na Liang Xianfeng Gong Weiwei An Yoshiaki Kawashima Fude Cui Pengfei Yan

In this study, we designed and developed a new drug delivery system of multifunctional composite microcapsules for oral administration of insulin. Firstly, in order to enhance the encapsulation efficiency, insulin was complexed with functional sodium deoxycholate to form insulin-sodium deoxycholate complex using hydrophobic ion pairing method. Then the complex was encapsulated into poly(lactide...

Journal: :Journal of Polymer Research 2022

Abstract A novel method for multi-finishing cellulosic fabrics is based on the consolidation of a thin layer active material containing micro-gels, titanium nanoparticles and silica. The titanium@silica core–shell particles were synthesized characterized their morphological, structural, compositional properties using X-ray diffraction scanning electron microscopy. are approximately 250 nm in si...

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