The aim of the present study was to develop a single unit, site-specific matrix tablets of aceclofenac allowing targeted drug release in the colon with a microbially degradable polymeric carrier, chondroitin suphate (CS) and to coat the optimized batches with a pH dependent polymeric. The tablets were prepared by wet granulation method using starch mucilage as a binding agent and HPMC K-100 ...

A key challenge in drug delivery systems is the real time monitoring of delivered drug and subsequent response. Recent advancement in nanotechnology has enabled the design and preclinical implementation of novel drug delivery systems (DDS) with theranostic abilities. Herein, fluorescent cerium fluoride (CeF3) nanoparticles (nps) were synthesized and their surface modified with a coat of polyeth...

Specific delivery of therapeutic agents to solid tumors and their bioavailability at the target site are the most clinically important and challenging goals in cancer therapy. Liposomes are promising nanocarriers and have been well investigated for cancer therapy. In spite of preferred accumulation in tumors via the enhanced permeability and retention (EPR) effect, inefficient drug release at t...

As a pH-sensitive nanomaterial, Eudragit S100 has good colon targeting. However, little research been carried out on its mesoscopic scale. In this paper, the self-assembly behavior of Pulsatilla saponins D (PSD) and S100, as well loading release mechanism PSD, was investigated via computer simulations. The effects characteristics PSD in dry powder state drug-carrier ratio were explored by coars...

Strategies used to enhance liposome-mediated drug delivery in vivo include the enhancement of stability and circulation time in the bloodstream, targeting to specific tissues or cells, and facilitation of intracytoplasmic delivery. pH-sensitive liposomes have been developed to mediate the introduction of highly hydrophilic molecules or macromolecules into the cytoplasm. These liposomes destabil...

nanoparticles have been at the center of research focus as a new promising material for the treatment of cancer in recent years. although many chemotherapy drugs for cancer treatment are available, their potential toxicity is the main point of concern. on the other hand, the conventional chemotherapeutic approach has not been found to be very efficient in colorectal cancer (crc) as the drug mol...

background: several multiphase flow analyses have been developed to predict the fate of particles used in inhalation drug delivery; however, the collapse of droplets during their passage through respiratory tract has not been investigated. objective: to assess the probability of droplet collapse in the upper respiratory tract. methods: a 3d model of mouth-to-second generation airway after the t...