Newly translated tubulin molecules undergo a series of complex interactions with nascent chain-binding chaperones, including prefoldin (PFD) and chaperonin-containing TCP-1 (CCT). By screening for oryzalin hypersensitivity, we identified several mutants of Arabidopsis that have lesions in PFD subunits. The pfd6-1 mutant exhibits a range of microtubule defects, including hypersensitivity to oryz...

We have developed a new database that collects all protein folding data into a single, easily accessible public resource. The Protein Folding Database (PFD) contains annotated structural, methodological, kinetic and thermodynamic data for more than 50 proteins, from 39 families. A user-friendly web interface has been developed that allows powerful searching, browsing and information retrieval, ...

In aquatic ecosystems, the superimposition of mixing events to the light diel cycle exposes phytoplankton to changes in the velocity of light intensity increase, from diurnal variations to faster mixing-related ones. This is particularly true in coastal waters, where diatoms are dominant. This study aims to investigate if coastal diatoms differently activate the photoprotective responses, xanth...

Apple ( Malus × domestica ) growers can incur significant economic losses when fruit drop before they be harvested [preharvest (PFD)]. In some years and cultivars, more than 30% of potential yield lost. Growers frequently apply plant bioregulators to reduce PFD, either via delay in maturity [aminoethoxyvinylglycine (AVG), 1-methylcycolpropene] or inhibition production cell hydrolysis enzymes th...

Design and simulation of Digital PLL has been illustrated in this paper. The Digital PLL is given signal of 400 MHz to 900 MHz in the UNII (Unlicensed National Information Infrastructure) lower band which is used by IEEE 802.11(a). All the Digital PLL blocks are designed and simulated using Simulink. It is verified that Digital PLL is stable with a phase margin of 91.1 degree which satisfy the ...

OBJECTIVES The Brazilian constitution guarantees the right to health, including access to medicines. In May 2004, Brazil's government announced the "Farmácia Popular" Program (FPP) as a new mechanism to improve the Brazilian population's access to medicines. Under FPP, a selected list of medicines is subsidized by the government and provided in public and private pharmacies. The aim of this stu...

Traditional hazard and operability analysis (HAZOP) is one of the most widely applied methods for process safety management in enterprises. Due to its principles based on conservative qualitative judgment, it often leads too risk identification results fluorine chemical industry usually with high-risk processes keep continuity production. Most improved quantitative semi-quantitative are layer p...

The subject of this paper is fast numerical algorithms for factoring univariate polynomials with complex coefficients and for computing partial fraction decompositions (PFDs) of rational functions in C(z). Numerically stable and computationally feasible versions of PFD are specified first for the special case of rational functions with all singularities in the unit disk (the ``bounded case'') a...

OBJECTIVE To analyse the development of pelvic organ prolapse (POP) after subtotal (SH) and total hysterectomy (TH) in the long-term, and to assess patient-reported symptoms regarding pelvic floor dysfunction (PFD). DESIGN Long-term follow-up study of a randomised controlled multicentre study. SETTING Seven hospitals and one private clinic in the south-east of Sweden. POPULATION Of the 18...