A 2-year-old patient with a history of non-Hodgkin's lymphoma (NHL) was presented to our hospital with the complaint of shortness of breath and wheezing. Posteroanterior chest radiograph revealed hyperlucency and hyperexpansion of the right hemithorax. We performed computed tomography (CT) because of a suspicion of foreign body aspiration. CT revealed right main bronchus occlusion by a hypodens...

BACKGROUND Bone marrow biopsy is considered essential for the staging and risk-adapted treatment of Hodgkin's lymphoma with unfavorable risk features. We reviewed the cases of pediatric Hodgkin's lymphoma in our institution to determine the impact of bone marrow involvement on treatment, relapse, and survival. DESIGN AND METHODS We reviewed the clinical characteristics and outcome of 383 pati...

Lymphomas (~1700 cases/yr.) are the third most common subgroup of pediatric cancers in the U.S., comprising about 15% of cancer that occurs before age 20. The incidence of lymphomas increases significantly from 0-20, with lymphomas accounting for about 3% of tumors 0-5 years and 24% 1519 years. The two major subcategories of lymphoma are Hodgkin’s disease (HD; 850-900 cases/yr) and Non-Hodgkin’...

In recent years, the number of approved and investigational agents that can be safely administered for the treatment of lymphoma patients for a prolonged period of time has substantially increased. Many of these novel agents are evaluated in early-phase clinical trials in patients with a wide range of malignancies, including solid tumors and lymphoma. Furthermore, with the advances in genome se...

Fortunately, few cases of primary cutaneous lymphoma and mycosis fungoides (MF) are seen in pediatric patients. In my experience, as head of the Lymphoma Unit at Hospital Universitario Basurto, in Bilbao, Spain, I have seen just 2 cases of MF, both classic, with an onset before the age of 18 years. The course of disease was more aggressive than usual in both patients. One of the patients died a...

Paravertebral malignant tumors constitute 4.8% of cancer cases in pediatric oncology and are mostly composed of neuroblastoma (46.4%) and soft tissue sarcomas (35.7%). We describe the case of a Caucasian 6-year-old boy who was admitted for middle back pain radiated to limbs and progressively increasing weakness of the legs, suggesting a spinal cord disease. The exploration revealed two paravert...

Burkitt’s lymphoma is a highly aggressive lymphoma often presenting at extranodal sites or as an acute leukemia. It is synonymous with L3 B ALL in the FAB, small non-cleaved cell, Burkitt’s type in the working formulation (WF). Historically, the prognosis in adults was poor despite early CR rates, however, recently more dose-intense regimens with CNS prophylaxis similar to pediatric regimens ha...

Intussusception is a common cause of bowel obstruction in the pediatric population. Malignant lesions account for up to 30 % of all cases of intussusception in the small intestine. We herein report an interesting case of ileo-colic intussusception caused by diffuse large B-cell lymphoma, in a child. The patient underwent laparoscopic right hemicolectomy. Pathologic evaluation revealed a diffuse...

Burkitt lymphoma (BL), a tumor occurring in endemic, sporadic and AIDS-associated forms, is the classic example of a human malignancy whose pathogenesis involves a specific cellular genetic change, namely, a chromosomal translocation deregulating expression of the c-myc oncogene, complemented in many cases by the action of an oncogenic virus, the Epstein-Barr virus (EBV). Here we review recent ...

Topical calcineurin inhibitors (TCIs), commercially available since 2000-2001, are the first and only topical medications approved for chronic treatment of atopic dermatitis (AD) in pediatric patients and remain a welcomed alternative to topical corticosteroids. In January 2006, the US Food and Drug Administration (FDA) issued a boxed warning requirement based on a theoretical risk of malignanc...