نتایج جستجو برای: paraquat dichloride

تعداد نتایج: 5267  

Journal: :British journal of pharmacology 1979
A R Boobis M J Brodie C J Bulpitt D S Davies

using lung and liver microsomes in the presence of paraquat, to generate superoxide and covalently bind a metabolite of DOPA. Male Wistar rats (150-250 g) were killed by decapitation and their lungs were perfused with ice cold normal saline. The lungs and livers were removed, homogenised and the microsomal fraction was isolated by differential centrifugation. The covalent binding of DOPA to was...

Journal: :iranian red crescent medical journal 0
mohammad ali davarpanah department of infectious diseases, gastroenterohepatology research center, shiraz university of medical sciences, shiraz, ir iran farideh hosseinzadeh student research committee, school of medicine, shiraz university of medical sciences, shiraz, ir iran s. saeed mohammadi student research committee, school of medicine, shiraz university of medical sciences, shiraz, ir iran; student research committee, school of medicine, shiraz university of medical sciences, shiraz, ir iran. tel: +98-9364402630

conclusions immediate and adequate use of antioxidants and hemodialysis has an undeniable and important role in survival of patients after ingestion of a large amount of paraquat. case presentation the present case report introduced a 25-year-old male with nausea, vomiting, and severe substernal burning sensation after incidentally ingestion of a large amount of paraquat. the treatment of the p...

Journal: :Movement disorders : official journal of the Movement Disorder Society 2012
Samuel M Goldman Freya Kamel G Webster Ross Grace S Bhudhikanok Jane A Hoppin Monica Korell Connie Marras Cheryl Meng David M Umbach Meike Kasten Anabel R Chade Kathleen Comyns Marie B Richards Dale P Sandler Aaron Blair J William Langston Caroline M Tanner

Paraquat is one of the most widely used herbicides worldwide. It produces a Parkinson's disease (PD) model in rodents through redox cycling and oxidative stress (OS) and is associated with PD risk in humans. Glutathione transferases provide cellular protection against OS and could potentially modulate paraquat toxicity. We investigated PD risk associated with paraquat use in individuals with ho...

Journal: :Environmental research 2016
Gamola Z Fortenberry John Beckman Abby Schwartz Joanne Bonnar Prado Lucia S Graham Sheila Higgins Michelle Lackovic Prakash Mulay Heidi Bojes Justin Waltz Yvette Mitchell Kathy Leinenkugel Michel S Oriel Elizabeth Evans Geoffrey M Calvert

BACKGROUND Paraquat and diquat are among the most commonly used herbicides in the world. OBJECTIVES Determine the magnitude, characteristics, and root causes for acute paraquat- and diquat-related illnesses in the US METHODS: Illnesses associated with paraquat or diquat exposure occurring from 1998 through 2011 were identified from the Sentinel Event Notification System for Occupational Risks...

2015
Woojae Myung Geung-Hee Lee Hong-Hee Won Maurizio Fava David Mischoulon Maren Nyer Doh Kwan Kim Jung-Yoon Heo Hong Jin Jeon Thomas Niederkrotenthaler

The annual suicide rate in South Korea is the highest among the developed countries. Paraquat is a highly lethal herbicide, commonly used in South Korea as a means for suicide. We have studied the effect of the 2011 paraquat prohibition on the national suicide rate and method of suicide in South Korea. We obtained the monthly suicide rate from 2005 to 2013 in South Korea. In our analyses, we ad...

2012
Sujin Seok Young-hee Kim Hyo-wook Gil Ho-yeon Song Sae-yong Hong

To identify a prognostic marker that is less sensitive to variations in the elapsed time since paraquat ingestion, we assessed the time between paraquat ingestion and a negative dithionite urine test as a prognostic parameter in patients with acute paraquat intoxication. Forty-one patients with acute paraquat intoxication were enrolled in this study and analyzed to verify significant determinan...

Journal: :The Journal of biological chemistry 2005
Mona Thiruchelvam Olga Prokopenko Deborah A Cory-Slechta Brian Buckley Oleg Mirochnitchenko

Oxidative stress has been implicated in the pathogenesis of Parkinson disease based on its role in the cascade of biochemical changes that lead to dopaminergic neuronal death. This study analyzed the role of oxidative stress as a mechanism of the dopaminergic neurotoxicity produced by the combined paraquat and maneb model of the Parkinson disease phenotype. Transgenic mice overexpressing either...

Journal: :Toxicology in vitro : an international journal published in association with BIBRA 2004
Francisco Peixoto Joaquim Vicente Vítor M C Madeira

Rat liver mitochondria are much more susceptible to protein oxidation induced by paraquat than plant mitochondria. The unsaturated index and the peroxidizability index are higher in rat than in potato tuber. The levels of superoxide dismutase and glutathione reductase are concurrent with the different sensitivities to paraquat, with higher activities in plant mitochondria. However, glutathione ...

Journal: :Acta Crystallographica Section E Structure Reports Online 2008

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید