S Benzimidazoles act as good ligand to transition metal ions and they exhibit several coordination modes. The synthesis of hetero-chelates of the type ML2.2H2O has been reported here.The metal complex of Co(II) and Ni(II) Complexes have been synthesized with 6-(difluoromethoxy)-2-[(3,4dimethoxypyridin-2-yl)methylsulfinyl]-1H-benzo[d]imidazole (Pantoprazole). Pantoprazole is a proton pump inhibi...

Methods Ten patients were evaluated (6 M:4 F; age 41.7 ± 4.3 y; admission APACHE II score 19.4 ± 1.9; pantoprazole n = 4, and placebo n = 6) from a larger prospective study, in which 209 mechanically ventilated patients were randomised to receive IV pantoprazole (40 mg) or placebo in a double-blind fashion. Patients who received ≥ 5 doses of pantoprazole/placebo (80 patients in total) were elig...

OBJECTIVE This paper reviews the pharmacology, clinical efficacy, and tolerability of pantoprazole in comparison with those of other available proton pump inhibitors (PPIs). METHODS Relevant English-language research and review articles were identified by database searches of MEDLINE, International Pharmaceutical Abstracts, and UnCover, and by examining the reference lists of the articles so ...

Imatinib mesylate (signal transduction inhibitor 571, Gleevec) is a potent and selective tyrosine kinase inhibitor, which was shown to effectively inhibit platelet-derived growth factor–induced glioblastoma cell growth preclinically. However, in patients, a limited penetration of imatinib into the brain has been reported. Imatinib is transported in vitro and in vivo by P-glycoprotein (P-gp; ABC...

BACKGROUND AND PURPOSE There is controversy and little information about whether individual proton pump inhibitors (PPIs) differentially alter the effectiveness of clopidogrel in reducing ischemic stroke risk. We, therefore, aimed to elucidate the risk of ischemic stroke among concomitant users of clopidogrel and individual PPIs. METHODS We conducted a propensity score-adjusted cohort study o...

Gastroesophageal reflux disease (GERD) is a chronic, relapsing disease that can progress to major complications. Affected patients have poorer health-related quality of life than the general population. As GERD requires continued therapy to prevent relapse and complications, most patients with erosive esophagitis require long-term acid suppressive treatment. Thus GERD results in a significant c...

The impact of the CYP2C19*17 allele on the pharmacokinetics of pantoprazole and omeprazole in previously studied children (n 40) was explored. When pantoprazole area under the plasma concentration versus time curve (AUC) was examined as a function of CYP2C19 genotype, a significantly lower AUC was observed for subjects identified as CYP2C19*1/*1 and *1/*17. For pantoprazole, a statistically sig...

31 Proton pump inhibitors reduce gastric acid secretion and are commonly utilized in 32 the management of gastro-esophageal reflux disease (GERD) across all ages. Yet a 33 decrease in lower esophageal sphincter tone has been reported in vitro in rats 34 through an unknown mechanism, however their effect on the gastroesophageal 35 muscle tone early in life was never studied. Hypothesizing that p...

The present study was undertaken to elucidate the effect of pantoprazole and aprepitant on experimental esophagitis in albino rats. Groups of rats, fasted overnight, received normal saline (3 mL/kg, sham control) or toxic control (3 mL/kg) or pantoprazole (30 mg/kg) or aprepitant (10 mg/kg), or their combinations and were subjected to pylorus and forestomach ligation. Animals were sacrificed af...