background:non-melanoma skin cancer (nmsc), the most prevalent types being squamous cell carcinoma (scc) and basal cell carcinoma (bcc), is the most common type of malignancy in human beings. these neoplasms are more frequent in the elderly and fair skinned people and mainly occur on sun-exposed sites of the body. ultraviolet b (uvb) has a well-known effect in induction and promotion of growth ...

Abstract Background Silica exposure underlies the development of silicosis, one most serious occupational hazards worldwide. We aimed to explore interaction silica-induced epithelial–mesenchymal transition (EMT)-related transcripts with cellular metabolism regulated by p53. Methods knocked out p53 using CRISPR/Cas9 in human bronchial epithelial (HBE) cell line. The transcriptomic and metabolomi...

One of the most commonly used drugs in chemotherapy, 5‑fluorouracil (5‑FU) has been shown to be effective only 10‑15% patients with colon cancer. Thus, studies mechanisms affecting 5‑FU sensitivity these are necessary. The tumor suppressor protein p53 is a transcription factor that serves important roles cell apoptosis by regulating cycle. It also characterized as key influencing drug sensitivi...

Trabeculectomy is the gold standard procedure performed in glaucoma when topical medication and laser intervention failed. In a trabeculectomy, number of clinical trials have shown efficacy ranibizumab minimizing extracellular matrix accumulation at filtering site. Ranibizumab (LucentisTM) drug that targets vascular endothelial growth factor (VEGF). However, to date actual mechanisms this anti-...

Background There are 2 known pathways for tumorigenesis of vulvar squamous cell carcinoma—a human papillomavirus–dependent pathway characterized by p16 overexpression and a papillomavirus–independent linked to lichen sclerosus, TP53 mutation. A correlation papillomavirus dependency with favorable prognosis has been proposed. Objective The objective the study was further understand role p53 stat...

Background: Melatonin as the major hormone produced by the pineal gland has a significant role in mammalian reproduction. In this study the efficacy of melatonin coadministration with nicotine on mouse follicogenesis was investigated. Materials and Methods: A total of 32 Female adult NMRI mice were divided into four groups. The control group (n=8) received vehicle, group 2 (n=8) received nicoti...

Introduction: The continuous rapid growth of the telecommunications industry and common application of cell phones have raised debates on the human health risks associated with exposure to radio frequency fields due to these phones or their base stations and other sources such as radar, radio/television waves, and industrial and medical applications. This study aimed to invest...

Recognition of the molecular mechanisms of cAMP action against DNA damage-induced apoptosis can be useful to improve the efficacy of DNA damaging therapeutic agents. Considering the critical role of bcl-2-associated death promoter (BAD) and p53 proteins in DNA damage -induced apoptosis, the aim of this study was to assess the effect of cAMP-elevating agents on these proteins in doxorubicin-trea...