نتایج جستجو برای: p2x3

تعداد نتایج: 460  

Journal: :Evidence-Based Complementary and Alternative Medicine 2020

2016
Yao Chou Tsai Lori Birder Hann-Chorng Kuo

PURPOSE The aim of this study was to analyze patterns of sensory protein expression and urothelial dysfunction in ketamine-related cystitis (KC) in humans. METHODS Biopsies of bladder mucosa were performed in 29 KC patients during cystoscopy. Then specimens were analyzed for tryptase, zonula occludens-1 (ZO-1), E-cadherin, and terminal deoxynucleotidyl transferase-mediated dUTP nick end-label...

Journal: :Molecular pharmacology 2007
George R Dubyak

P2X receptors (P2XR) function as ATP-gated nonselective ion channels permeable to Na+, K+, and Ca2+, and they are expressed in a wide range of excitable, epithelial/endothelial, and immune effector cell types. The channels are trimeric complexes composed of protein subunits encoded by seven different P2XR genes expressed in mammalian and other vertebrate genomes. Current genetic, biochemical, a...

Journal: :Glycobiology 2011
Fabrizio Vacca Nadia D'Ambrosi Valeria Nestola Susanna Amadio Michela Giustizieri Maria Letizia Cucchiaroni Alessandro Tozzi Marie Claire Velluz Nicola Biagio Mercuri Cinzia Volonté

N-Glycosylation affects the function of ion channels at the level of multisubunit assembly, protein trafficking, ligand binding and channel opening. Like the majority of membrane proteins, ionotropic P2X receptors for extracellular ATP are glycosylated in their extracellular moiety. Here, we used site-directed mutagenesis to the four predicted N-glycosylation sites of P2X(3) receptor (Asn(139),...

Journal: :The Journal of physiology 2000
W Rong G Burnstock K M Spyer

A novel in vitro intra-arterially perfused adult rat tongue-nerve preparation was used to explore the possible actions of P2X purinoceptor agonists (ATP and alpha,beta-methylene ATP (alpha, beta-meATP)) on sensory nerve terminals innervating the rat tongue. We made whole-nerve recordings of the trigeminal branch of the lingual nerve (LN), which conducts general sensory information (pain, temper...

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