نتایج جستجو برای: ns1

تعداد نتایج: 2089  

Journal: :Journal of immunology 2005
Chiou-Feng Lin Shu-Chen Chiu Yu-Ling Hsiao Shu-Wen Wan Huan-Yao Lei Ai-Li Shiau Hsiao-Sheng Liu Trai-Ming Yeh Shun-Hua Chen Ching-Chuan Liu Yee-Shin Lin

Vascular dysfunction is a hallmark associated with disease onset in dengue hemorrhagic fever and dengue shock syndrome. In addition to direct viral damage, immune responses to dengue virus (DV) infection may also underlie the pathogenesis of disease. We have proposed a mechanism of molecular mimicry in which Abs directed against DV nonstructural protein 1 (NS1) cross-react with endothelial cell...

2005
Jürg P. F. Nüesch Jean Rommelaere

During a productive infection, the prototype strain of the parvovirus minute virus of mice (MVMp) induces dramatic morphological alterations in permissive A9 fibroblasts, culminating in cell lysis at the end of infection. These cytopathic effects (CPE) result from rearrangements and destruction of the cytoskeletal microand intermediate filaments, while other structures such as the nuclear lamin...

2017
Sujuan Chen Yinbiao Zhu Da Yang Yang Yang Shaohua Shi Tao Qin Daxin Peng Xiufan Liu

H9N2 avian influenza virus is a zoonotic agent with a broad host range that can contribute genetic information to H5 or H7N9 subtype viruses, which are significant threats to both humans and birds. Thus, there is a great need for a vaccine to control H9N2 avian influenza. Three mutant viruses of an H9N2 virus A/chicken/Taixing/10/2010 (rTX-NS1-73, rTX-NS1-100, and rTX-NS1-128) were constructed ...

Journal: :The Southeast Asian journal of tropical medicine and public health 2011
Fauziah Md Kassim M Nur Izati T A R TgRogayah Y Mohd Apandi Zainah Saat

Accurate and timely diagnosis of dengue virus is important for early detection of dengue virus infection. In this study, the usefulness of the dengue NS1 antigen test was evaluated as a routine, rapid diagnostic test for dengue virus infection. A total of 208 sera from patients suspected of having dengue virus infection were collected and tested for dengue antibody, dengue genome and dengue NS1...

2017
Margery G Smelkinson Annabel Guichard John R Teijaro Meghana Malur Maria Eugenia Loureiro Prashant Jain Sundar Ganesan Elina I Zúñiga Robert M Krug Michael B Oldstone Ethan Bier

The multifunctional NS1 protein of influenza A viruses suppresses host cellular defense mechanisms and subverts other cellular functions. We report here on a new role for NS1 in modifying cell-cell signaling via the Hedgehog (Hh) pathway. Genetic epistasis experiments and FRET-FLIM assays in Drosophila suggest that NS1 interacts directly with the transcriptional mediator, Ci/Gli1. We further co...

Journal: :Clinical and vaccine immunology : CVI 2011
Xixia Ding Dongmei Hu Yue Chen Biao Di Jing Jin Yuxian Pan Liwen Qiu Yadi Wang Kun Wen Ming Wang Xiaoyan Che

Dengue virus (DENV), a member of the Flavivirus family, has four distinct serotypes (DENV serotype 1 [DENV1], DENV2, DENV3, and DENV4) that require differentiation for the effective prevention of morbid disease. Early and rapid differentiation between flaviviruses remains challenging. Full assays combining four individual, serotype-specific and one group-specific nonstructural protein 1 (NS1) a...

2016
Omer Abid Kathum Tobias Schräder Darisuren Anhlan Carolin Nordhoff Swantje Liedmann Amit Pande Alexander Mellmann Christina Ehrhardt Viktor Wixler Stephan Ludwig

Phosphorylation and dephosphorylation acts as a fundamental molecular switch that alters protein function and thereby regulates many cellular processes. The non-structural protein 1 (NS1) of influenza A virus is an important factor regulating virulence by counteracting cellular immune responses against viral infection. NS1 was shown to be phosphorylated at several sites; however, so far, no fun...

Journal: :The Journal of general virology 1987
J J Schlesinger M W Brandriss E E Walsh

Immunization of mice with the dengue 2 virus (DEN 2)-specified non-structural protein NS1 provided significant protection against intracerebral challenge with the virus in the absence of detectable neutralizing or other anti-virion antibody. NS1, purified from lysates of infected Vero cells by immunoaffinity chromatography, expressed an antigenic site(s) common to each of the four DEN serotypes...

2017
M. J Killip D Jackson M Pérez-Cidoncha E Fodor R. E Randall

Deletion or truncation of NS1, the principal IFN antagonist of influenza viruses, leads to increased IFN induction during influenza virus infection. We have studied activation of the IFN induction cascade by both wild-type and NS1-defective viruses at the single-cell level using a cell line expressing GFP under the control of the IFN-β promoter and by examining MxA expression. The IFN-β promote...

2017
Broc T. McCune Wei Tang Jia Lu James B. Eaglesham Lucy Thorne Anne E. Mayer Emily Condiff Timothy J. Nice Ian Goodfellow Andrzej M. Krezel Herbert W. Virgin

The Norovirus genus contains important human pathogens, but the role of host pathways in norovirus replication is largely unknown. Murine noroviruses provide the opportunity to study norovirus replication in cell culture and in small animals. The human norovirus nonstructural protein NS1/2 interacts with the host protein VAMP-associated protein A (VAPA), but the significance of the NS1/2-VAPA i...

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