Glioma stem cells (GSCs) exhibit stem cell properties and high resistance to radiotherapy. The main aim of our study was to determine the roles of ROS in radioresistance and stemness of GSCs. We found that microRNA (miR)-153 was down-regulated and its target gene nuclear factor-erythroid 2-related factor-2 (Nrf-2) was up-regulated in GSCs compared with that of non-GSCs glioma cells. The enhance...

It has been known for years that, after chemical damage or surgical removal of its tissue, the liver initiates a series of changes that, taken together, are known as regeneration, which are focused on the recovery of lost or affected tissue in terms of the anatomical or functional aspect. The Nuclear factor-erythroid 2-related factor (Nrf-2) is a reduction-oxidation reaction (redox)-sensitive t...

As part of the Phase III luminosity upgrade, the Cornell Electron-Positron Storage Ring (CESR) RF system has been upgraded from normal conducting (NRF) to superconducting (SRF) cavaties. The new superconducting cavities change the overall impedance of CESR and thus change the longitudinal bunch distribution. Measurements of the single bunch longitudinal distribution have been made using a strea...

Abstract Forkhead transcription factor (FoxO) plays key roles in the induction of various downstream genes involved inhibition cellular metabolism, cell death, cycle, and oxidative stress responses. FoxO6 is expressed liver, skeletal muscle, hippocampus brain. also has been proposed to play a role promotion insulin resistance, inflammation. In this study, we tried determine neuroinflammation in...

Objective(s): Aspiration is a common cause of acute lung injury (ALI), which lacks an effective treatment. Inflammation and oxidative stress play key roles in ALI development. Silymarin is an active extract of Silybum marianum plant seeds (milk thistle). Silymarin has potent anti-inflammatory and antioxidant effects; however its role in aspiration induced ALI has not b...

This paper makes the detailed analyses of computational complexities and related parameters selection on our proposed constrained learning neural network root-finders including the original feedforward neural network root-finder (FNN-RF) and the recursive partitioning feedforward neural network root-finder (RP-FNN-RF). Specifically, we investigate the case study of the CLA used in neural root-f...

Abstract The ongoing pandemic of COVID-19, caused by SARS-CoV-2 infection, has threatened the global health. Since first case infection was reported in December 2019, rapidly spread all over world and millions deaths. As vaccination is best way to protect host from invading pathogens, several vaccines have been developed prevent saved huge numbers lives so far. However, constantly change their ...

Abstract Accumulating data have highlighted the role of monocytes/macrophages in immune escape by generating immunologically “cold” tumors that do not respond to immunotherapy. CD244 (SLAMF4, 2B4), a member signaling lymphocyte activation molecule family, is expressed on myeloid cells, but its precise has been elucidated. Using monocyte lineage-specific CD244-deficient micechallenged with B16F1...