Background Human dermal papilla (DP) cells and melanocytes (hMel) are central players in hair growth pigmentation, respectively. In follicles (HFs), oxygen (O2) levels average 5%, being coupled with the production of reactive species (ROS), necessary to promote growth. Materials Methods DP cell hMel proliferation phenotype were studied under physiological (5%O2, physoxia) or atmospheric (21%O2,...

UNLABELLED This demonstrates a MR imaging method to measure the spatial distribution of pulmonary blood flow in healthy subjects during normoxia (inspired O(2), fraction (F(I)O(2)) = 0.21) hypoxia (F(I)O(2) = 0.125), and hyperoxia (F(I)O(2) = 1.00). In addition, the physiological responses of the subject are monitored in the MR scan environment. MR images were obtained on a 1.5 T GE MRI scanner...

A series of novel 3-phenyl-2-ethylthio/ethylsulfinyl/ethylsulfonyl/phenylthio/ phenylsulfonyl-quinoxaline 1,4-dioxide derivatives were synthesized and screened for their cytotoxicity in vitro on human leukaemia cell line HL-60, human esophagus cancer cell line ECA-109, human prostate cancer cell line PC-3, human gastric carcinoma cell line SGC-7901, and human breast cancer cell line MCF-7 in hy...

Gender differences in neuropsychiatric disease are recognized but not well understood. Investigating the survival of primary rat hippocampal neurons in culture, we found significant and inverted gender differences on normoxia versus hypoxia. Male cells were more resistant under normoxia but more vulnerable under hypoxia than female cells. Male vulnerability pattern was acquired in cells from ne...

The routine metabolic rate of Pseudocrenilabrus multicolor victoriae, laboratory-reared, F1 offspring of parents collected from a hypoxic swamp, did not differ between sibs raised under normoxia and hypoxia. In the offspring of parents originating from a river where the oxygen levels were generally high but fluctuating, the metabolic rate of fish raised under normoxia was higher than for sibs r...

DNA replication and repair in eukaryote cells are critical processes that ensures the correct transfer of material through mitosis. Errors during following cell division may lead to genome instability. PURPOSE: To investigate regulation select gene transcripts aligned exercise hypoxia. METHODS: Twenty-four (n = 24) apparently healthy male participants were recruited (age 28 ± 5 years; mass 74 8...

Abstract AIMS Glioblastomas (GBMs) are characterised by highly hypoxic regions and the ability to invade into healthy brain tissue promoting tumour dissemination recurrence; development of novel anti-migratory inhibitors target cell invasion recurrence must consider varying treatment responses in this background. As proof principle we investigated activity two, previously characterised, small m...

In cancer, treatment failure and disease recurrence have been associated with small subpopulations of cancer cells a stem-like phenotype. this paper, we develop investigate phenotype-structured model solid tumour growth in which are structured by stemness level, varies continuously between terminally differentiated behaviours. Cell evolution is driven proliferation death, as well advection diff...