background and aims. connective tissue grafts with and without periosteum is used in regenerative treatments of bone and has demonstrated successful outcomes in previous investigations. the aim of present study was to evaluate the effectiveness of connective tissue graft with and without periosteum in regeneration of intrabony defects. materials and methods. in this single-blind randomized spli...

For the past two decades, nonlinear microscopy has been developed to overcome the scattering problem in thick tissue imaging. Owing to its increased imaging depth and high spatial resolution, nonlinear microscopy becomes the first choice for imaging living tissues. The use of nonlinear optical effects not only facilitates the signal originating from an extremely small volume defined by light fo...

This paper deals with a chemotaxis-haptotaxis model of cancer invasion of tissue. The model consists of three reactiondiffusion-taxis partial differential equations describing interactions between cancer cells, matrix degrading enzymes, and the host tissue. The equation for cell density includes two bounded nonlinear density-dependent chemotactic and haptotactic sensitivity functions. In the ab...

A probabilistic framework is presented that enables image registration, tissue classification, and bias correction to be combined within the same generative model. A derivation of a log-likelihood objective function for the unified model is provided. The model is based on a mixture of Gaussians and is extended to incorporate a smooth intensity variation and nonlinear registration with tissue pr...

The elastic response behavior of brain tissue in vivo has been shown to be sensitive to the physiological environment of the brain and thus represents a useful parameter for identifying effects of controlled changes on the system. Here we describe a method for measuring brain elastic response using an epidural pressure-depth transducer and a minimum number of insertions. The method also serves ...

A nonlinear, Bayesian optimization scheme is presented for reconstructing fluorescent yield and lifetime, the absorption coefficient, and the diffusion coefficient in turbid media, such as biological tissue. The method utilizes measurements at both the excitation and the emission wavelengths to reconstruct all unknown parameters. The effectiveness of the reconstruction algorithm is demonstrated...

Much has been learned about the viscoelastic properties of the true vocal fold, including its linear and nonlinear viscoelastic properties under both tensile and shear deformation. Very little is known about the viscoelastic behavior of the false vocal fold, however. Clinical observations and computational modeling studies of phonation have suggested that the false fold could contribute to the ...

We consider the combined effects of active dendrites and structural plasticity on the storage capacity of neural tissue. We compare capacity for two different modes of dendritic integration: (1) linear, where synaptic inputs are summed across the entire dendritic arbor, and (2) nonlinear, where each dendritic compartment functions as a separately thresholded neuron-like summing unit. We calcula...

In the theory of weakly nonlinear elasticity, Hamilton et al. [J. Acoust. Soc. Am. 116, 41-44 (2004)] identified W=muI(2)+(A/3)I(3)+DI(2) (2) as the fourth-order expansion of the strain-energy density for incompressible isotropic solids. Subsequently, much effort focused on theoretical and experimental developments linked to this expression in order to inform the modeling of gels and soft biolo...

Ultrasound (US) thermotherapy is used to treat tumours, located deep in human tissue, by heat. It features by the application of high intensity focused ultrasound (HIFU), high local temperatures of about 90 degrees C and short treating time of a few seconds. Dosage of the therapy remains a problem. To get it under control, one has to know the heat source, i.e. the amount of absorbed US power, w...