Immune status and target organ histology were temporally evaluated in mice fed either carcinogenic 5-nitrofurans or their noncarcinogenic nornitro analogs. Mice were fed either the leukemogen A/-[4-(5-nitro-2-furyl)-2-thiazolyl]acetamide (NFTA) or the urinary bladder carcinogen A/-[4-(5-nitro-2-furyl)2-thiazolyl]formamide or their nornitro analogs, A/-[4-(2-furyl)2-thiazolyl]acetamide or A/-{4-...

Immune status and target organ histology were temporally evaluated in mice fed either carcinogenic 5-nitrofurans or their noncarcinogenic nornitro analogs. Mice were fed either the leukemogen A/-[4-(5-nitro-2-furyl)-2-thiazolyl]acetamide (NFTA) or the urinary bladder carcinogen A/-[4-(5-nitro-2-furyl)2-thiazolyl]formamide or their nornitro analogs, A/-[4-(2-furyl)2-thiazolyl]acetamide or A/-{4-...

The in vitro activities of 39 antimicrobial agents against 23 isolates of Treponema hyodysenteriae, the majority of which were field isolates, were determined by the agar dilution technique. Quinoxalines, pleuromutilin, nitroimidazoles, and nitrofuran were the most active. Their activities ranged from </=0.10 to 1.56 mug/ml. Lincomycin, penicillins, chloramphenicol, tetracyclines, cephalosporin...

Furazolidone (FZD), a synthetic nitrofuran derivative, has been widely used as an antibacterial and antiprotozoal agent. Recently, the potential toxicity of FZD has raised concerns, but its mechanism is still unclear. This study aimed to investigate the protective effect of curcumin on FZD-induced cytotoxicity and the underlying mechanism in human hepatocyte L02 cells. The results showed that c...

The carcinogenicity of N-( 5-Nitro-2-furfurylidene )-1-aminohydan to in (nitrofurantoin, NF-153) was examined in (C57BL/6N x DBA/2N)F1 (BDF1) mice. Three hundred of mice were divided into three groups, each group consisting about 50 male and 50 female mice. Nitrofurantoin was given in powdered diet at dose levels of 0. 3, 0. 075, or 0 % to the respestive group of mice. The overall incidence of ...

BACKGROUND Nifuroxazide (NF) is an oral nitrofuran antibiotic, having a wide range of bactericidal activity against gram positive and gram negative enteropathogenic organisms. It is formulated either in single form, as intestinal antiseptic or in combination with drotaverine (DV) for the treatment of gastroenteritis accompanied with gastrointestinal spasm. Spectrofluorimetry is a convenient and...