نتایج جستجو برای: neurotoxicity syndromes
تعداد نتایج: 85645 فیلتر نتایج به سال:
Therapy-related neurotoxicity greatly affects possibility of survival and quality of life of pediatric patients treated for cancer. Central nervous system (CNS) involvement is heterogeneous, varying from very mild and transient symptoms to extremely severe and debilitating, or even lethal syndromes. In this review, we will discuss the broad scenario of CNS complications and toxicities occurring...
The development of neuropathic syndromes is an important, dose limiting side effect of anticancer agents like platinum derivates, taxanes and vinca alkaloids. The causes of neurotoxicity are still unclear but the impairment of the oxidative equilibrium is strictly related to pain. Two intracellular organelles, mitochondria and peroxisomes cooperate to the maintaining of the redox cellular state...
background: acrylamide (acr) is a well-known industrial toxic chemical that produces neurotoxicity, which is characterized by progressive central and peripheral neuronal degeneration. chrysin is a natural, biologically active flavonoid compound, which is commonly found in many plants. the antioxidant and neuroprotective properties of chrysin have been demonstrated. methods: in this study, the p...
Explanation.................................................................................................. 149 Evaluation for acceptable daily intake......................................................... 150 Biochemical aspects........................................................................... 150 Absorption, distribution and excretion ....................................... 150 B...
Explanation ..................................................................................................... 227 Evaluation for acceptable daily intake ............................................................ 228 1. Biochemical aspects .......................................................................... 228 1.1 Absorption, distribution and excretion .................................
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The neurofibrillary degeneration that occurs in Alzheimer's disease (AD) is thought to be the result of a chronic and damaging neuroinflammatory response mediated by neurotoxic substances produced by activated microglial cells. This neuroinflammation hypothesis of AD pathogenesis has led to numerous clinical trials with anti-inflammatory drugs, none of which have shown clear benefits for slowin...
adenosine in the ostial lesions, and in sufficiently high doses if by the intracoronary method. Some studies have shown that intracoronary adenosine infusion does not attain the maximum hyperaemic state2,3 and that, as the team in Murcia has shown,4 only doses much higher than those initially recommended (>60 μg) achieve that effect. Finally, with respect to the technique to be used, one should...
This is the report of the first workshop on Incorporating In Vitro Alternative Methods for Developmental Neurotoxicity (DNT) Testing into International Hazard and Risk Assessment Strategies, held in Ispra, Italy, on 19-21 April 2005. The workshop was hosted by the European Centre for the Validation of Alternative Methods (ECVAM) and jointly organized by ECVAM, the European Chemical Industry Cou...
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