Traumatic brain injury is considered as one of the main causes of morbidity and mortality worldwide. Apart from primary mechanical injury, Secondary injuries due to inflammation and apoptosis result in great neuronal damage. Current treatments are not able to regenerate the damaged part and prevent future sequels. Using human stem cells with self-assembling scaffolds may be promising in treatme...

background: the failure of regeneration after spinal cord injury (sci) has been attributed to axonal demyelination and neuronal death. cellular replacement and white matter regeneration are both necessary for sci repair. in this study, we evaluated the co-transplantation of olfactory ensheathing cells (oec) and embryonic stem (es) cell-derived motor neurons (esmn) on contused sci. methods: oec ...

Background: Neurofilament light chain protein (NfL) and tau are plasma biomarkers of neuronal injury which can be elevated in patients with neurodegenerative diseases. N-terminal pro-brain natriuretic peptide (NT-proBNP) is an established marker volume status heart failure (HF) cBIN1 score (CS) emerging biomarker cardiac muscle health. It not known if, HF patients, there a correlation between m...

Aging is known to play a critical role in the etiopathogenesis of several diseases. Among them, cardiovascular disorders are especially relevant since they becoming first cause death western countries. Resveratrol polyphenolic compound that has been shown exert beneficial effects at different levels, including neuronal and protection. Those resveratrol related, least part, its antioxidant anti-...

Background: the general lifespan has been prolonged greatly during past century, and incidence of age-associated diseases, including neurodegenerative ones, increased as well. However, modelling age-related pathologies is mostly conducted on adult rodents. We studied morphofunctional changes in brain peripheral blood Wistar rats comparison with old to determine physiological differences adaptiv...

Abstract Objectives Brain imaging techniques have broadened our understanding of structural and functional properties neuronal networks in children with developmental disabilities. The present work examines current models response implicated dyslexia reading difficulties. Methods This review analyzes the use (fMRI EEG) employed assessment markers associated ability. Results Neuro-imaging studie...

Peripheral primitive neuroectodermal tumor now termed as Ewings sarcoma/PNET, representing a family of tumors with varying degrees neuronal differentiation and genetic rearrangements. Most common sites are extraosseous involving trunk lower limb. Base tongue is very rare site for Ewing’s/PNET, hence in view rarity the location an uncommon presentation, case has been reported better understandin...

Transient ischemia causes delayed neurodegeneration in selective brain areas, particularly in the CA1 field of the hippocampus. This is accompanied by neurovascular impairment. It is unknown whether neurodegeneration is the cause or consequence of vascular changes. In an entorhino-hippocampal-organotypic slice culture system with well-preserved blood vessels, we studied the interplay between ne...

Bidirectional cell trafficking between fetus and mother during pregnancy is a well-established phenomenon observed in placental vertebrates including humans. Although studies have shown that transmigratory fetal cells, also termed pregnancy-associated progenitor cells (PAPCs), can integrate into multiple maternal organs, the integration, long-term survival, and differentiation of PAPCs in the b...