The antibody activity of a benign IgG lambda paraprotein to nerve tissue in a case of peripheral neuropathy has been investigated using immunohistochemical methods on tyrpsin-treated, formalin-fixed, paraffin-embedded tissue. IgG lambda was found in th sural nerve biopsy of the patient. Specific binding of the purified IgG lambda paraprotein and its isolated F(ab')2 fragment to homologous nerve...

Peripheral nerve regeneration occurs spontaneously after injury due to the permissive environment and activation of intrinsic growth capacity neurons. Injuries can be divided into three categories: neurapraxia, axonotmesis neurotmesis. Wallerian degeneration neurotmesis, affecting axon distal site damage. After this phase is complete, damaged neurons try rebuild fibers with axonal budding. Axon...

BACKGROUND Various pathological conditions such as inflammation or injury can evoke pain hypersensitivity. That represents the response to innocuous stimuli or exaggerated response to noxious stimuli. The molecular mechanism based on the pain hypersensitivity is associated with changes in many of ion channels in dorsal-root ganglion (DRG) neurons. Anoctamin 1 (ANO1/TMEM16A), a Ca2+ activated ch...

Regional anesthesia (RA) is an interplay between the local anesthetic (LA) solution and neural structures, resulting in nerve conduction blockade. For that, it necessary to understand which hurdles LA has overcome components of nerves are involved. Background knowledge non-neural helps locate safest area for deposition. In addition, physiology process patterns block onset, involved fibers, regr...

Peripheral nerves are organ-like structures containing diverse cell types to optimize function. This interactive assembly includes mostly axon-associated Schwann cells, but also endothelial cells of supporting blood vessels, immune system-associated barrier-forming the perineurium surrounding and protecting nerve fascicles, connective tissue-resident within intra-fascicular endoneurium inter-fa...