نتایج جستجو برای: nerve agents

تعداد نتایج: 517326  

2015
Kayla M. Hackman Bhuvana Shyam Doddapaneni Connor W. Barth Igor H. Wierzbicki Adam W. G. Alani Summer L. Gibbs

Nerve damage during surgery is a common morbidity experienced by patients that leaves them with chronic pain and/or loss of function. Currently, no clinically approved imaging technique exists to enhance nerve visualization in the operating room. Fluorescence image-guided surgery has gained in popularity and clinical acceptance over the past decade with a handful of imaging systems approved for...

Journal: :Drug and chemical toxicology 2015
Peter E Rezk Pierre Zdenka Praveena Sabnekar Takwen Kajih David G Mata Chester Wrobel Douglas M Cerasoli Nageswararao Chilukuri

In this study, we determined the ability of recombinant human liver prolidase to hydrolyze nerve agents in vitro and its ability to afford protection in vivo in mice. Using adenovirus containing the human liver prolidase gene, the enzyme was over expressed by 200- to 300-fold in mouse liver and purified to homogeneity by affinity and gel filtration chromatography. The purified enzyme hydrolyzed...

Journal: :Diabetes care 2004
Vera Bril Yoshiyuki Ono Robert A Buchanan

OBJECTIVE Nerve sorbitol levels have been measured in sural nerve biopsy samples from patients with diabetic sensorimotor polyneuropathy in several studies using different methods and measurement units. In this study, we compared the results of sorbitol assays to determine the required sensitivity of analytical methods for nerve sorbitol measurements. RESEARCH DESIGN AND METHODS We performed ...

2010
Tsung-Ming Shih Robert K. Kan John H. McDonough

The purpose of this project was to determine and compare the time-related changes in blood, brain, and tissue acetylcholinesterase (AChE) activity during the first hour after exposure to six organophosphorus nerve agents (GA, GB, GD, GF, VR, and VX) in Hartley guinea pigs. Animals were pretreated with atropine methyl nitrate (1.0 mg/kg, i.m.) to minimize peripheral toxic effects 15 min before t...

Journal: :Biochemistry 2007
Chunyuan Luo Min Tong Nageswararao Chilukuri Karen Brecht Donald M Maxwell Ashima Saxena

The reactivation of nerve agent-inhibited acetylcholinesterase (AChE) by oxime is the most important step in the treatment of nerve agent poisoning. Since the evaluation of nerve agent antidotes cannot be conducted in humans, results from animal experiments are extrapolated to humans. Guinea pig is one of the animal models that is frequently used for conducting nerve agent antidote evaluations....

2005
Alberto Sánchez Arribas Terannie Vázquez Joseph Wang Ashok Mulchandani Wilfred Chen

A new biometallization route for detecting low levels of organophosphorus nerve agents based on organophosphorus-hydrolase (OPH)-stimulated formation of cupric-ferrocyanide (CuFeCN) nanoparticles is described. The growth and accumulation of these nanoparticles onto the surface of carbon paste electrodes, coupled with their favorable redox activity, allow the amplified electrochemical detection ...

Journal: :basic and clinical neuroscience 0
mohamed abdelhamid ali yousef experimental surgery and microsurgery research unit, department of general surgery, university of pavia, v.le golgi 19, 27100, pavia, italy. paolo dionigi organization stefania marconi organization alberto calligaro organization antonia icaro cornaglia organization enrico alfonsi organization

introduction: repair of peripheral nerve injuries is an intensive area of challenge and research in modern reconstructive microsurgery. intensive research is being carried out to develop effective alternatives to the standard nerve autografting, avoiding its drawbacks. the aim of the study was to evaluate the effectiveness of a newly designed mechanical device for the reconstruction of the scia...

Journal: :medical journal of islamic republic of iran 0
jalal arabloo health management and economics research center, iran university of medical sciences & department of health management and economics, school of public health, tehran university of medical sciences, tehran, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences) serajaddin grey deprtment of health management and economics, school of public health, tehran university of medical sciences, tehran, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences) mohammadreza mobinizadeh young researchers and elites club, science and research branch, islamic azad university, tehran, iran.سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (islamic azad university science and research branch) alireza olyaeemanesh national institute for health research, tehran university of medical sciences, tehran, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences) pejman hamouzadeh deprtment of health management and economics, school of public health, tehran university of medical sciences, tehran, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences) kiumars khamisabadi national institute for health research, tehran university of medical sciences, tehran, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences)

background: maggot therapy has recently attracted considerable attention as an emerging debridement technique for wound healing. this study aimed to review the safety, effectiveness and economic evaluations of maggot debridement therapy for wound healing.   methods: to retrieve the relevant evidences, the cochrane library (until september 2014) was searched by appropriate keywords, using free t...

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