We consider online competitive algorithms for the problem of collecting weighted items froma dynamic set S, when items are added to or deleted from S over time. The objective isto maximize the total weight of collected items. We study the general version, as well asvariants with various restrictions, including the following: the uniform case, when all itemshave the same weight, ...

acrjourna erogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) has been reported to be overexpressed in ancer and in other cancers such as breast, pancreas, and liver. However, a mechanism linking hnRNP A2/ rexpression and progression to cancer has not yet been definitively established. To elucidate this mech, we have silenced hnRNPA2/B1 mRNA in non–small-cell lung cancer cell lines A549, H...

A proton NMR method for the determination of the solvation numbers of alkaline earth cations with dimethylsulfoxide (DMSO) in nitromethane as diluent is described. The method is based on the monitoring of the resonance frequency of DMSO protons as a function of DMSO to metal ion mole ratio while keeping the metal ion concentration constant. The average solvation number of cations at any...

Background Gestational trophoblastic disease (GTD) defines a heterogenenous group of interrelated lesions that arise from the trophoblastic epithelium of the placenta. There are several histologically distinct types of GTD: hydatiform mole (complete or partial), persistant/invasive gestational trophoblastic neoplasia (GTN), choriocarcinoma and placenta site trophoblastic tumors. The aim of this...

3 " If we were not able or did not desire to look in any new direction, if we did not have a doubt or recognize ignorance, we would not get any new ideas. There would be nothing worth checking, because we would know what is true. So what we call scientific knowledge today is a body of statements of varying degrees of certainty. Some of them are most unsure; some of them are nearly sure; but non...

Downlo ivated oncogenes are the dominant drivers of malignant progression in human cancer, yet little is known how the transformation from proto-oncogene to activated oncogene drives the expression of transd phenotypes. An isogenic model of HER-2–mediated transformation of human mammary epithelial as used along with HER-2–amplified human breast cancers to investigate how HER-2 activation alters...