PURPOSE Monocyte chemoattractant protein (MCP)-1 (CCL-2) is a chemokine with chemoattractant properties for monocytes, memory T cells, natural killer cells, mast cells, and basophils. To delineate the role played by MCP-1 in acute anterior uveitis, a common ocular inflammation, MCP-1(-/-) mice and wild-type matched control mice were analyzed for the development of endotoxin-induced uveitis (EIU...

To achieve high-speed communication, it is well-known that the per-byte overhead needs to be minimized. The advances of gigabit networks highlight the importance of so-called lightweight primitives in order to utilize the available bandwidth. Asynchronous UDP [1] is one of such primitives proposed recently. This paper evaluates Asynchronous UDP over Myrinet. We describe the design and implement...

Infiltrating leukocytes may be responsible for autoimmune disease. We hypothesized that the chemokine monocyte chemoattractant protein (MCP)-1 recruits macrophages and T cells into tissues that, in turn, are required for autoimmune disease. Using the MRL-Fas(lpr) strain with spontaneous, fatal autoimmune disease, we constructed MCP-1-deficient MRL-Fas(lpr) mice. In MCP-1-intact MRL-Fas(lpr) mic...

The CC chemokine Monocyte Chemoattractant Protein (MCP)-1/CCL2 has potent mononuclear cell chemo-attractant properties, modulates fibroblast and endothelial cell phenotype and may play an important role in wound healing. In order to examine whether MCP-1 critically regulates myocardial infarct healing, we studied the effects of MCP-1 gene disruption and antibody neutralization in a closed-chest...

The coding region for the major capsid protein (MCP) of human cytomegalovirus (HCMV) was identified by comparing the protein sequence with the respective sequences of herpes simplex virus (HSV), Epstein-Barr virus, and varicella-zoster virus. The predicted length of the HCMV MCP was 1,370 amino acids. Comparison of the MCP sequences of the different human herpesviruses showed a homology of 25% ...

green olive cultivars “manzanila” and “mission” were harvested at the mature green stage. they were either treated with 1-methylcyclopropane (1-mcp) at a concentration of 1.8 µl/l for 24 h at 20°c or kept untreated as a control. both treated and untreated fruits were then immersed in water containing cacl2 of 0 (control), 50 and 100 mm for 2 h under 1.2 bar pressure. fruits were then surface dr...

Neuroinflammation involving CC chemokines such as monocyte chemoattractant protein-1 (MCP-1) has been demonstrated in the pathological process of retinitis pigmentosa (RP), an inherited degenerative retinal disease. However, the mechanism of MCP-1 and its receptor CCR2 involvement in the disease remains unclear. To investigate the role of MCP1/CCR2 in RP pathogenesis, ccr2 mutant RP mice (ccr2(...

In this monograph, the impact of cooperation on the performance of wireless cellular systems is studied from an information-theoretic standpoint, focusing on simple formulations typically referred to as Wynertype models. Following ongoing research and standardization efforts, the text covers two main classes of cooperation strategies. The first class is cooperation at the base station (BS) leve...

OBJECTIVE The efficiency of HSV-tk/GCV system is not high because of insufficient gene transfer and incompletely initiative of host antineoplastic potency. The present study was designed to assess the antitumor efficacy of tk-MCP-1 on ovarian cancer in vitro and vivo. METHODS A novel bicistronic expression system can help to improve the expression level of a gene in a stable manner. pLXSN/tk-...

Monocyte chemotactic protein-4 (MCP-4) is a newly identified C-C chemokine with potent eosinophil chemoattractant properties. We describe studies of its biological activity in vitro to induce chemotaxis of peripheral blood eosinophils and to induce histamine release from IL-3-primed peripheral blood basophils. MCP-4 and eotaxin caused a similar rise in eosinophil intracytoplasmic Ca2+ and compl...