OBJECTIVE In this study, we determined the assay performance criteria necessary to produce acceptable results for >or=98% of neonate bilirubin samples collected by capillary heel-stick. STUDY DESIGN AND METHODS We determined serum free hemoglobin levels in 151 heel-stick serum samples to determine the hemolysis level. We then tested the effect of hemolysis on total bilirubin levels determined...

This paper presents a new approach to modeling speech spectra and pitch for text-independent speaker identification using Gaussian mixture models based on multi-space probability distribution (MSD-GMM). The MSD-GMM allows us to model continuous pitch values for voiced frames and discrete symbols representing unvoiced frames in a unified framework. Spectral and pitch features are jointly modeled...

neurocysticercosis, is the infection caused by the larval form of the tapeworm taenia solium. it is considered as the most common parasitic disease of the central nervous system and the most common cause of acquired epilepsy. this has primarily been a disease that remains endemic in countries with poor economy , but because of increased migration neurocysticercosis is being diagnosed more frequ...

We compared information obtained by both microscopy and nested mitochondrial cytochrome b PCR in determining prevalence of haemosporidian infections in naturally infected birds. Blood samples from 472 birds of 11 species belonging to 7 families and 4 orders were collected in Europe, Africa and North America. Skilled investigators investigated them using the PCR-based screening and microscopic e...

which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Microscopic colitis (MC) is characterized by chronic watery diarrhea. MC comprises two entities: collagenous colitis (CC) and lymphocytic colitis (LC), which are separated by typical histopathological characteristics. The colonic mucosa appears endoscopicall...

INTRODUCTION Current laboratory testing of Lyme borreliosis mostly relies on serological methods with known limitations. Diagnostic modalities enabling direct detection of pathogen at the onset of the clinical signs could overcome some of the limitations. Molecular methods detecting borrelial DNA seem to be the ideal solution, although there are some aspects that need to be considered. Areas co...

Due to the development of nanotechnology graphene and graphene-based nanomaterials have attracted the most attention owing to their unique physical, chemical, and mechanical properties. Graphene can be applied in many fields among which biomedical applications especially diagnostics, cancer therapy, and drug delivery have been arousing a lot of interest. Therefore it is essential to understand ...

To be accurate and equivalent, laboratory results should be traceable to higher-order references. Furthermore, their analytical performance should fulfill acceptable measurement uncertainty criteria defined to fit the intended clinical use. With this aim, In Vitro Diagnostics (IVD) manufacturers should define a calibration hierarchy to assign traceable values to their system calibrators and to ...

OBJECTIVES The aim of this study was to develop a novel method for automated quantification of cell-free hemoglobin (fHb) based on the HI (Roche Diagnostics). METHODS The novel fHb method based on the HI was correlated with fHb measured using the triple wavelength methods of both Harboe [fHb, g/L = (0.915 * HI + 2.634)/100] and Fairbanks et al. [fHb, g/L = (0.917 * HI + 2.131)/100]. fHb conce...