The Buccal Micronucleus Cytome (BMCyt) in exfoliated buccal epithelial cells is a minimally invasive method for assessing chromosomal instability, DNA damage and cell death. It has been widely used in occupational and lifestyle related studies. For the present study 63 male subjects were taken out of which 32 were vegetarian and 31 subjects were nonvegetarian matched with respect to their age, ...

Aim: The aim of this review was to evaluate the scientific literature regarding cytogenetic damage in oral exfoliated cells adult patients submitted panoramic X-ray. Materials and Methods: An extensive search conducted on PubMed, Scopus Web Science databases for all studies published until April 2021 using combinations following keywords: “panoramic X-ray,” “DNA damage,” “genetic damage”, “geno...

Enhanced sensitivity to the chromosome-damaging effects of ionizing radiation is a feature of many cancer-predisposing conditions. It has been suggested that women with breast cancer are deficient in the repair of radiation-induced DNA damage. We have now investigated whether mutagen sensitivity is related to mutations in the breast cancer gene BRCA1. We studied the induction and repair of DNA ...

The studies presented here were designed to elucidate the enzymes involved in the biotransformation of naturally occurring 1, 8-dihydroxyanthraquinones and to investigate whether biotransformation of 1,8-dihydroxyanthraquinones may represent a bioactivation pathway. We first studied the metabolism of emodin (1, 3,8-trihydroxy-6-methylanthraquinone), a compound present in pharmaceutical preparat...

The aim of the present study was to perform cytogenetic analysis by means of a semi‑automated micronucleus‑centromere assay in lymphocytes from medical radiation workers. Two groups of workers receiving the highest occupational doses were selected: 10 nuclear medicine technicians and 10 interventional radiologists/cardiologists. Centromere‑negative micronucleus (MNCM‑) data, obtained from these...

DNA repair is an essential mechanism for cells to maintain their genomic integrity under endogenous or exogenous assault. Reduced DNA repair capacity (DRC) is associated with increased risk for several environmentally related cancers. The micronucleus in peripheral lymphocytes has been validated as a biomarker of chromosomal damage, increasing cancer risk in human populations. We hypothesized t...