Recent studies have implicated synucleins in several reactions during the biosynthesis of lipids and fatty acids addition to their recognised role membrane lipid binding synaptic functions. These are among aspects decreased synuclein functions that still poorly acknowledged especially regard pathogenesis Parkinson’s disease. Here, we aimed add existing knowledge deficiency (i.e., lack all three...

BackgroundThe nuclear receptor farnesoid X (FXR) is a key regulator of hepatic BA and lipid metabolism, inflammation fibrosis. Here, we aimed to explore the potential cilofexor, non-steroidal FXR agonist, as therapeutic approach for counteracting features cholestatic liver injury by evaluating efficacy mechanisms in Mdr2/Abcb4 knockout (-/-) mouse model sclerosing cholangitis.MethodsFVB/N WT Md...

Obesity has caused serious economic and health problems in the world. Gut microbiota is a complex ecosystem plays an important role preventing obesity. The purpose of this study was to investigate effects Ganoderma amboinense (G. amboinense) polysaccharide (GAP) on obesity-related characteristics high-fat-diet (HFD) mice, determine whether GAP treatment can regulate gut HFD-mice. extracted from...

Orally administered Ag2S quantum dots (QDs) rapidly cross the small intestine and are taken up by liver. Metformin nicotinamide mononucleotide (NMN) target metabolic aging processes within This study examined pharmacology toxicology of QD-based nanomedicines as carriers metformin NMN in young old mice, determining if their therapeutic potency reduced effects associated with could be improved. P...

Abstract The intestinal immune system is a central modulator of obesity-associated metabolic disease. Particularly, high-affinity IgA maintains gut homeostasis after its generation in germinal center (GC) response that requires functional T follicular helper (Tfh) cells Peyer’s patches (PP). objective this study was to determine how obesity affects Tfh function leading We investigated the pheno...

In this study, the therapeutic effect of Mel-incubated Adipose-derived mesenchymal stem cells (ADSCs) on CCl4-induced hepatic fibrosis was investigated. Mice with were intraperitoneally injected 8% CCl4 twice a week for 4 weeks. Starting from 5, mice in ADSC group and + Mel 1 mL PBS cell suspension containing × 106 ADSCs or pretreated 50 nM 2 consecutive Results: model group, severe histopathol...

Liver ischemia and reperfusion (IR) injury is the major complication of liver-related operations. Macrophage polarization has an essential effect on mechanism liver IR injury. Vitamin D receptor (VDR) been found to regulate macrophage alleviate Nevertheless, correlation between VDR in not clearly elucidated. knockout mice wild-type littermates underwent partial for 90 min 6 h. RAW264.7 cells we...

This study analyzed the effects of 24 h cold stress (22°C or 5°C vs. mice maintained at 30 °C) on plasma, brown adipose tissue (BAT), subcutaneous (SubQ) and epididymal (Epi) white (WAT), liver, skeletal muscle lipidome mice. Using mass spectrometry-lipidomics, 624 lipid species were detected, which 239 significantly altered in 134 BAT, 51 liver. In acylcarnitines free fatty acids markedly incr...

Bromobenzene (BB) is known to pose a serious threat human health. We previously demonstrated that BB showed chronotoxicity, is, daily fluctuations in the severity of hepatotoxicity induced mice. Although mild nephrotoxicity, fluctuation was not observed this toxicity. This might be attributed fact BB-induced chronotoxicity only liver and kidneys damage caused by prominent liver, masking nephrot...