BACKGROUND The question for prevalence estimation and validation of the various eGFRs in old age is still under debate. To assess renal function with increasing age, we estimated mean eGFR, in subjects aged 20-85 years. Furthermore, we assessed prevalence of eGFR in a population-based sample of 85 year olds and investigated the performance of these eGFRs in predicting mortality in the oldest ol...

Women with a history of preeclampsia have a 5- to 12-fold increased risk to develop end-stage kidney disease. Previous observations in small cohorts suggest that former preeclamptic (fPE) women have subtle abnormalities in renal hemodynamics and renal function, which might predispose them to renal failure in later life. In this study, we analyzed renal function in a cross-sectional cohort consi...

We read with interest the article “A prospective study about impact of renal dysfunction and morbidity and mortality on cardiovascular events after ischemic stroke” by Penko et al. [1]. They aimed at investigating the impact of renal dysfunction on future cardiovascular (CV) events and total mortality in patients suffering from ischemic stroke. They demonstrated that the patients with ischemic ...

AIMS To evaluate the quality of bedside estimation of glomerular filtration rate (GFR) in hospitalized elderly patients. METHODS We evaluated common estimators of GFR in 29 women and 32 men aged 60 and older hospitalized in a geriatric ward: creatinine clearance (CCR), the Cockcroft-Gault formula (CG), the modification of diet in renal disease formula (MDRD), Baracskay formula (BAR), and a ne...

BACKGROUND Estimation of the glomerular filtration rate (GFR) at the bedside is important because renal insufficiency is related to increased mortality and morbidity. A discrepancy between the Cockroft-Gault (CG) and the Modification of Diet in Renal Disease (MDRD) formulas has been observed in older people. OBJECTIVE To compare the GFR of inpatients aged 65 or older estimated using the CG an...

BACKGROUND The performance of creatinine-based glomerular filtration rate (GFR) estimating equations may vary in subgroups defined by GFR, age and body mass index (BMI). This study compares the performance of the Modification of Diet in Renal Disease (MDRD) study and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations with the revised Lund-Malmö equation (LM Revised), a new eq...

BACKGROUND Accurate and precise estimates of glomerular filtration rate (GFR) are essential for clinical assessments, and many methods of estimation are available. We developed a radial basis function (RBF) network and assessed the performance of this method in the estimation of the GFRs of 207 patients with type-2 diabetes and CKD. METHODS Standard GFR (sGFR) was determined by (99m)Tc-DTPA r...

OBJECTIVE To determine Serum Cystatin C (S.CysC) levels in healthy potential kidney donors and its correlation with Serum Creatinine (S.Cr), Glomerular filtration rate (GFR) by 24 hour urinary Creatinine clearance (CCL) and GFR by formulae of Cockcroft Gault (CCG) and Modification of diet in Renal Disease (MDRD). METHODS A Cross sectional study was conducted at Sindh Institute of Urology and ...

Serum creatinine is measured more than 280 million times annually in the United States, and more than 80% of clinical laboratories now report an estimated glomerular filtration rate (GFR) when serum creatinine is measured.1,2 The most commonly used equation is the Modification of Diet and Renal Disease (MDRD) Study equation. Recently, the Chronic Kidney Disease Epidemiology Collaboration (CKD-E...

BACKGROUND Black individuals are far more likely than white individuals to develop end stage renal disease (ESRD). However, earlier stages of chronic kidney disease (CKD) have been reported to be less prevalent among blacks. This disparity remains poorly understood. The objective of this study was to evaluate whether the lower prevalence of CKD among blacks in early stages of CKD might be due i...