نتایج جستجو برای: macrolides
تعداد نتایج: 4269 فیلتر نتایج به سال:
We have synthesized new derivatives of the macrolide antibiotics erythromycin and azithromycin. Novel deoxysugar moieties were attached to these standard antibiotics by biotransformation using a heterologous host. The resulting compounds were tested against several standard laboratory and clinically isolated bacterial strains. In addition, they were also tested in vitro against standard and dru...
The macrolide antibiotics include natural members, prodrugs and semisynthetic derivatives. These drugs are indicated in a variety of infections and are often combined with other drug therapies, thus creating the potential for pharmacokinetic interactions. Macrolides can both inhibit drug metabolism in the liver by complex formation and inactivation of microsomal drug oxidising enzymes and also ...
Chronic obstructive pulmonary disease (COPD) and other inflammatory airway conditions are major causes of morbidity and mortality worldwide. Antibiotics are used to treat acute infectious exacerbations of airway disease. However, for the macrolides, a significant and growing body of evidence indicates that anti-inflammatory effects of these antibiotics, which may be independent of their antibac...
OBJECTIVES To study mutations at positions A2058, A2503 and U2504 (Escherichia coli numbering) of 23S rRNA and their relationship to resistance to antibiotics that target the large ribosomal subunit. METHODS Single and dual mutations at positions 2058, 2503 and 2504 of 23S rRNA were introduced into a Mycobacterium smegmatis strain with a single functional rRNA operon. MICs of macrolide, pleur...
Abstract Mycoplasma pneumoniae is one of the leading causes community-acquired pneumonia in children and adolescents. Because wide application macrolides clinical treatment, macrolide-resistant M. strains have become increasingly common worldwide. However, molecular mechanisms underlying drug resistance are poorly understood. In present work, we analyzed whole proteomes macrolide-sensitive usin...
Objective. The purpose of the research was to study features course acute purulent lymphadenites and adenophlegmons maxillofacial region in children, describe species composition pathogens, determine their sensitivity antibiotics various groups.
 Materials methods. medical histories 147 patients were analyzed; microbiological studies carried out (microscopic examination clinical specimens ...
Macrolide antibiotics are thought to clog up the ribosomal tunnel and thereby block general protein synthesis. By using a combination of elegant in vivo and in vitro approaches, Kannan et al. show that the inhibitory action of these drugs on bacterial protein synthesis is selective rather than global.
4 Robert Tarran, Juan R. Sabater, Tainya C. Clarke, 5 Chong D. Tan, Catrin M. Davies, Jia Liu, Arthur Yeung, 6 Alaina L. Garland, M. Jackson Stutts, William M. Abraham, 7 Gary Phillips, William R. Baker, Clifford D. Wright, Sibylle Wilbert 8 9 Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina, 10 Chapel Hill, NC, 27599; Gilead Sciences, Inc., Seattle, WA, 981...
BACKGROUND Large cohort studies provide conflicting evidence regarding the potential for oral macrolide antibiotics to increase the risk of serious cardiac events. OBJECTIVES This study performed a meta-analysis to examine the link between macrolides and risk of sudden cardiac death (SCD) or ventricular tachyarrhythmias (VTA), cardiovascular death, and death from any cause. METHODS We perfo...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید