The aim of this study was to evaluate the incidence of deep vein thrombosis (DVT) in patients with suspected pulmonary embolism (PE) and the relation between PE and the site of DVT by using technetium-99m-macroaggregated human serum albumin ((99m)Tc-MAA) radionuclide venography (RNV). Technetium-99m-MAA RNV was performed simultaneously with lung perfusion scintigraphy in 123 patients with s...

A 67-year-old woman with multiple myeloma and recently treated left upper pneumonia was admitted to the hospital for acute-onset shortness of breath. Chest radiography showed a left upper lobe infiltrate. CT angiography revealed right-sided pulmonary embolus. IV heparin was started through a new right subclavian central venous catheter. The patient was then transferred to the Methodist Hospital...

SUMMARY Macroaggregated serum albumin (MAA) particles labeled with 131iodine (1311) or similar particles-labeled with 99mtechnetium (99mTc) or both types were injected directly into the coronary circulation of 29 patients at the time of conventional coronary arteriography. Radionuclide images of the distribution of these small (10-60 gu) biodegradable particles in the small vessels of the heart...

Sir, A 12-year-old asymptomatic boy was referred for assessment with a history of a heart murmur noted at 2 years of age but subsequently lost to follow-up. Physical examination showed normal growth and development and an unremarkable cardiorespiratory exam. He had participated in multiple sports with no shortness of breath, chest pain, or syncope. An echocardiogram showed lack of bifurcation o...

Regional control of blood flow is often suggested as a mechanism for fine thermoregulatory adjustments in snakes. However, the flow of blood to different body regions at various temperatures has never been visualized to confirm this mechanism. We used (99m)technetium-labelled macroaggregated albumin ((99m)Tc-MAA), a radioactive tracer, to follow the flow of blood through the bodies of garter sn...

OBJECTIVE The purpose of this study was to determine the adsorption behavior of some widely used, commercially available 99mTc radiopharmaceuticals onto different types of plastic syringes. METHODS Kits were reconstituted with 99mTc-pertechnetate diluted with 0.9% saline to produce maximum radioactive concentrations, as stated by the manufacturers. Aliquots of the solutions were transferred t...

BACKGROUND/AIMS Aminopeptidase P (APP) is specifically enriched in caveolae on the luminal surface of pulmonary vascular endothelium. APP antibodies bind lung endothelium in vivo and are rapidly and actively pumped across the endothelium into lung tissue. Here we characterize the immunotargeting properties and pharmacokinetics of the APP-specific recombinant antibody 833c. METHODS We used in ...

To determine whether postural changes in ratio of upper to lower (U:L) zone pulmonary blood flow reflect pulmonary arterial pressures, we used pulmonary perfusion photoscintigraphy to study 12 normal subjects and 10 patients with precapillary pulmonary hypertension (eight classified as "primary" and two as thromboembolic). All patients underwent right-heart catheterization and measurement of pu...