Abstract Background Richter’s syndrome is the transformation of indolent lymphoma into an aggressive form, most commonly diffuse large B cell lymphoma. Most patients are known to have chronic lymphocytic leukemia. arises in lymph nodes or bone marrow and rarely presents with extra nodal involvement. Case presentation Our patient presented at extremely uncommon site, i.e., testis. This fourth ca...

Chronic lymphocytic leukemia is the most common leukemia in the United States. It is a slowly progressive disease, with an 82% five-year survival rate. The treatment strategies are highly individualized with patients in the early and stable stages typically not requiring treatment. However, those with progressive or clinically advanced disease will require treatment. Cytotoxic drugs, such as th...

conclusions according to this study, igvh3 mutation was found to be prevalent (although a correlation was found to exist between the patients’ survival and igvh mutation, it was not statistically significant). we can conclude that clinical methods are still valuable to predict the prognosis of patients with cll. given the high cost and need for specialized laboratory, determining the cost and v...

chronic lymphocytic leukemia (cll) remains an incurable disease that requires innovative new approaches to improve therapeutic outcome. many ferula species, including f. asa-foetida, synthesize terpenyloxy coumarins. one of these coumarins is umbelliprenin, which has been implicated with induction of apoptosis in some cancer cell lines.     in this study induction of apoptosis by umbelliprenin ...

BACKGROUND Morphology and cytochemistry are the foundation for classification of leukemias in dogs and cats. Advances in automated hematology instrumentation, immunophenotyping, cytogenetics, and molecular biology are significantly improving our ability to recognize and classify spontaneous myeloproliferative and lymphoproliferative disorders. OBJECTIVE The purpose of this study was to assess...

Leukocytes express a major sialoglycoprotein, leukosialin, of which the apparent molecular weight (mol wt) can be variable according to the differences in O-glycans attached to this molecule. In the present study, we analyzed the structures of O-glycans attached to leukosialin present in various T-lymphocytic leukemia cells. T-lymphoid cells from patients with acute T-lymphocytic leukemia expre...

Ferroptosis is a newly defined programmed cell death (PCD) process with the hallmark of accumulation iron-dependent lipid peroxidation, which more immunogenic over apoptosis. shows great potential as therapeutic target against acute kidney injury (AKI), cancers, cardiovascular diseases, neurodegenerative and hepatic diseases. Accumulating evidence has highlighted that ferroptosis plays an unneg...