نتایج جستجو برای: let 7
تعداد نتایج: 709904 فیلتر نتایج به سال:
Importance of the NCp7-like domain in the recognition of pre-let-7g by the pluripotency factor Lin28
The pluripotency factor Lin28 is a highly conserved protein comprising a unique combination of RNA-binding motifs, an N-terminal cold-shock domain and a C-terminal region containing two retroviral-type CCHC zinc-binding domains. An important function of Lin28 is to inhibit the biogenesis of the let-7 family of microRNAs through a direct interaction with let-7 precursors. Here, we systematically...
Innate immunity forms the first line of host defense. It is quick and usually shapes the adaptive immune responses which clear off the pathogens. However, dysregulated innate immune responses can lead to excessive inflammation which causes significant damage to the host. As a result, innate immune responses are tightly regulated. In this review, we focus on mechanisms by which microRNA let-7 re...
Previous studies have revealed the aberrant expression of a number of microRNAs (miRNA/miRs) in the blood circulation of patients with breast cancer (BC). The aim of the present study was to assess the effect of neoadjuvant chemotherapy on the levels of a panel of BC-associated miRNAs, which are at relatively low (let-7, miR-10b, miR-34, miR-155, miR-200c and miR-205) or abundant (miR-21, miR-1...
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