Leon H Charney Division of Cardiology; Cardiovascular Genetics Program; Dept of Pharmacology, NYU School of Medicine, New York, NY; Molecular Cardiology, Maugeri Foundation; Pavia, Italy; Del E. Webb Center for Neuroscience, Aging & Stem Cell Research, Sanford-Burnham Medical Research Institute, La Jolla, CA; Dept of Bioscience and Biotechnology, Sejong University, Seoul, Korea; Division of Car...

This paper contains a description of a network-based, Learning Environment Organizer entitled LEO, which takes its impetus from the Assimilation Theory of meaningful learning [1]. LEO represents a new approach to computer-mediated augmentation of face-to-face, or hybrid courses, and a different approach to distance learning course delivery. LEO provides the learner with a graphical advance orga...

PURPOSE To better understand the performance of four commercially available neurovascular stents in intracranial aneurysm embolization, the stents were compared in terms of their basic morphological and mechanical properties. MATERIALS AND METHODS Four different types of stents that are currently being used for cerebral aneurysm embolization were prepared (two stents per type). Two were laser...

The functional specialization or redundancy of the ubiquitous 14-3-3 proteins constitutes a fundamental question in their biology and stems from their highly conserved structure and multiplicity of coexpressed isotypes. We address this question in vivo using mutations in the two Drosophila 14-3-3 genes, leonardo (14-3-3zeta) and D14-3-3epsilon. We demonstrate that D14-3-3epsilon is essential fo...

Forrester’s model is described and critically analyzed with a view to understanding the relationship between his conclusions and his normative scheme. He claims that his model produces "counterintuitive" results; it is argued here that the main results follow directly from his goals. An alternative method of evaluating the results of the model is proposed, based upon the model’s calculation of ...

There is a growing consensus that developmental dyslexia is associated with a phonological-core deficit. One symptom of this phonological deficit is a subtle speech-perception deficit. The auditory basis of this deficit is still hotly debated. If people with dyslexia, however, do not have an auditory deficit and perceive the underlying acoustic dimensions of speech as well as people who read no...

We report initial experience with the use of a new intracranial stent, the Leo microstent in combination with detachable coils in treatment of patients with wide-necked cerebral aneurysms. The Leo stent represents a significant advance in the vascular treatment of intracranial aneurysm with high radial force and an easy delivery system. It is a feasible, secure, and effective system.

LEO-II, a resolution based theorem prover for classical higher-order logic, is currently being developed in a one year research project at the University of Cambridge, UK, with support from Saarland University, Germany. We briefly discuss the main objectives of the project. The LEO-II project is funded by EPSRC under grant EP/D070511/1.

The diameter velocity dispersion relation in B, V, and K for three early type galaxies in the Leo I (M96) group is derived from published photometry and kinematic data. The relations in all three colors have slopes which agree well with those for the Coma cluster. The RMS scatter of the Leo I galaxies in each color is extremely small, consistent with the group’s compactness. These relations yie...

The automated theorem prover Leo was one of the first systems able to prove theorems in higher-order logic. Since the first version of Leo many other systems emerged and outperformed Leo and its successor Leo-II. The Leo-III project’s aim is to develop a new prover reclaiming the lead in the area of higher-order theorem proving. Current competitive theorem provers sequentially manipulate sets o...