The recently discovered endoplasmic reticulum (ER) membrane protein complex (EMC) has been implicated in ER-associated degradation (ERAD), lipid transport and tethering between the ER and mitochondrial outer membranes, and assembly of multipass ER-membrane proteins. The EMC has been studied in both animals and fungi but its presence outside the Opisthokont clade (animals + fungi + related proti...

UMR CNRS 7205, Muséum National d’Histoire Naturelle, 45 rue Buffon, 75005 Paris, France LECA, BP 53, Université Joseph Fourier, 2233 Rue de la Piscine, 38041 Grenoble Cedex, France Smithsonian Tropical Research Institute, Apartado 2072, Balboa, Panama Department of Archaeology, University of Aberdeen, St. Mary’s Building, Elphinstone Road, Aberdeen AB24 3UF, UK UMR CNRS 7209, Muséum National d’...

Protein N-terminal acetylation is an ancient and ubiquitous co-translational modification catalyzed by a highly conserved family of N-terminal acetyltransferases (NATs). Prokaryotes have at least 3 NATs, whereas humans have six distinct but highly conserved NATs, suggesting an increase in regulatory complexity of this modification during eukaryotic evolution. Despite this, and against our initi...

Quorum sensing controls the virulence determinants in most proteobacteria. In this work, the hexane, chloroform and methanol extracts of an Ayurveda spice, namely clove (Syzygium aromaticum), shown anti-quorum sensing activity. Hexane and methanol extracts of clove inhibited the response of C. violaceum CV026 to exogenously supplied N-hexanoylhomoserine lactone, in turn preventing violacein pro...