نتایج جستجو برای: ionophores
تعداد نتایج: 4101 فیلتر نتایج به سال:
The highly selective cytotoxicity of site-directed ricin A chain conjugates can be potentiated by membrane-active carboxylic ionophores. The combined use of the two agents results in much faster inactivation of ribosomes and subsequent cell death and lysis. The potency of A chain cytotoxins is correspondingly increased by several orders of magnitude and cells that sparsely express the target an...
Hydraphile compounds are shown to be cytotoxic to Gram-negative and Gram-positive bacteria, yeast, and mammalian cells. Their cellular toxicity compares favorably with other synthetic ionophores and rivals that potency of natural antibiotics. The effects of structural variations on toxicity are described. The effects of these variations correlate well with previous studies of ion transport in l...
Octamethylcyclotetrasiloxane (OMCTS), a common constituent of household products, triggers the transformation of bismuth to the volatile toxic derivative trimethylbismuth by Methanosarcina barkeri, which is a representative member of the sewage sludge microflora. Comparative studies with the ionophores monensin and lasalocid, which induce effects similar to those observed for OMCTS, indicated t...
We present and validate an equilibrium model based on the Poisson-Boltzmann equations that includes main ingredients to simulate ion-sensitive membranes in context of electrochemical potentiometric sensors with without ionophores. With respect phase boundary models, our spatial resolution electrostatic potential concentrations. The enables study Nernstian non-Nernstian responses, helps improvin...
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