نتایج جستجو برای: inos protein

تعداد نتایج: 1236459  

Journal: :International Journal of Molecular Sciences 2023

Asthma is a chronic inflammatory lung disease that causes respiratory difficulties. Black ginseng extract (BGE) has preventative effects on diseases such as asthma. However, the pharmacological mechanisms behind anti-asthmatic activity of BGE remain unknown. To investigate mechanism BGE, phorbol 12-myristate 13-acetate plus ionomycin (PMA/Iono)-stimulated mouse EL4 cells and ovalbumin (OVA)-ind...

Journal: :Endocrinology 2006
Ebru Karpuzoglu Jillian B Fenaux Rebecca A Phillips Andrea J Lengi François Elvinger S Ansar Ahmed

Estrogen is implicated in many autoimmune diseases and is a robust immunomodulator. For example, it regulates interferon (IFN)-gamma, a cytokine believed to up-regulate inducible nitric oxide synthase (iNOS). A notable gap in the literature is a lack of information on the regulation of nitric oxide in immune tissues by estrogen. We now show that activation of splenocytes with T cell stimulants ...

Journal: :Hypertension 1998
T C Chou M H Yen C Y Li Y A Ding

The activity and protein expression of endothelial nitric oxide synthase (eNOS) and inducible NOS (iNOS) were investigated during the development of hypertension in spontaneously hypertensive rats (SHR). SHR and Wistar-Kyoto rats (WKY) were studied at three different ages: 4, 14 to 17, and 63 weeks of age. After treatment with saline or lipopolysaccharide (LPS, 10 mg/kg IV) for 3 hours, the aor...

Journal: :iranian journal of basic medical sciences 0
azam karkhaneh department of biochemistry, school of medicine, tehran university of medical sciences, tehran, iran reference laboratory, iranian social security organization, tehran, iran mohammad ansari department of biochemistry, school of medicine, tehran university of medical sciences, tehran, iran solaleh emamgholipour department of biochemistry, school of medicine, tehran university of medical sciences, tehran, iran mohammad hessam rafiee high institute for research and education in transfusion medicine, tehran, iran

objective(s):the neuropeptide calcitonin gene-related peptide (cgrp) has long been postulated to play an integral role in the pathophysiology of migraine. earlier studies showed that cgrp can stimulate the synthesis and release of nitric oxide (no) and cytokines from trigeminal ganglion glial cells. the purpose of this study was to determine the effect of 17β-estradiol in regulation of cgrp exp...

Journal: :Journal of neurochemistry 1995
H Fujisawa T Ogura A Hokari A Weisz J Yamashita H Esumi

Nitric oxide synthase (NOS) activity was induced in the cytosol of A-172 cells by treatment with lipopolysaccharide, tumor necrosis factor-alpha, and interferon-gamma. A 130-kDa human inducible NOS (iNOS) protein was detected with anti-rat iNOS antibody by western blot analysis. Northern blot analysis showed that the iNOS mRNA was approximately 4.5 kb, using a cDNA fragment for human iNOS, isol...

Journal: :Journal of applied physiology 2012
Raymond M Kraus Joseph A Houmard William E Kraus Charles J Tanner Joseph R Pierce Myung Dong Choi Robert C Hickner

The molecular mechanisms responsible for impaired insulin action have yet to be fully identified. Rodent models demonstrate a strong relationship between insulin resistance and an elevation in skeletal muscle inducible nitric oxide synthase (iNOS) expression; the purpose of this investigation was to explore this potential relationship in humans. Sedentary men and women were recruited to partici...

Journal: :The Journal of biological chemistry 2010
Tri M Bui-Nguyen Suresh B Pakala Divijendranatha Reddy Sirigiri Emil Martin Ferid Murad Rakesh Kumar

Nitric oxide has been implicated in the pathogenesis of inflammatory disorders, including hepatitis B virus-associated hepatocellular carcinoma. Transactivator protein HBx, a major regulator of cellular responses of hepatitis B virus, is known to induce the expression of MTA1 (metastasis-associated protein 1) coregulator via NF-kappaB signaling in hepatic cells. However, the underlying mechanis...

Journal: :FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007
Sandra Donnini Federica Finetti Raffaella Solito Erika Terzuoli Andrea Sacchetti Lucia Morbidelli Paola Patrignani Marina Ziche

In squamous cell carcinoma, the levels of nitric oxide (NO) derived from inducible NO synthase (iNOS) and prostaglandin E2 (PGE2) derived from cyclooxygenase-2 (COX-2) originated from tumor cells or tumor-associated inflammatory cells have been reported to correlate with tumor growth, metastasis, and angiogenesis. The present study examined the role of the iNOS signaling pathway in PGE2-mediate...

Journal: :American journal of physiology. Heart and circulatory physiology 2000
R Muniyappa R Xu J L Ram J R Sowers

Inducible nitric oxide synthase (iNOS) in vascular smooth muscle cells (VSMCs) is upregulated in arterial injury and plays a role in regulating VSMC proliferation and restenosis. Inflammatory cytokines [e.g., interleukin-1beta (IL-1beta)] released during vascular injury induce iNOS. Small GTP-binding proteins of the Ras superfamily play a major role in IL-1beta-dependent signaling pathways. In ...

Journal: :The Journal of biological chemistry 1998
K Pahan F G Sheikh M Khan A M Namboodiri I Singh

The sphingomyelin signal transduction pathway is known to play a role in mediating the action of various cytokines. Here we examined the possible role of the sphingomyelin signaling pathway on lipopolysaccharide (LPS)- and cytokine-mediated production of NO and the expression of inducible nitric-oxide synthase (iNOS). Sphingomyelinase (SMase) treatment of astrocytes increased the cellular level...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید